代谢干预与营养
NAD+ 前体、mTOR 抑制剂、GLP-1 受体激动剂、热量限制与限时进食。代谢是衰老最核心的驱动因素之一。
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← 返回专辑索引Treating soybean seedlings with TFM elicited a concentration-dependent behavioral response in third-instar nymphs, indicating clea…
Sarcopenia and reduced physical activity may decrease skeletal-muscle glucose utilization and aggravate insulin resistance, while …
Acute complications of diabetes and their symptoms must be managed while avoiding iatrogenic complications, particularly hypoglyce…
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These findings establish that UBE3A is expressed in neuronal populations involved in the regulation of feeding behavior and system…
Mitophagy-associated markers and mitochondrial function were assessed by Western blotting, quantitative real-time PCR, mitochondri…
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The prevalence of vitamin B12 deficiency differed significantly according to sex, duration of diabetes, and alcohol consumption (p…
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The permutation test used the 1,000 label permutations stated in the Methods; none of the 1,000 permuted datasets reached the obse…
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Recent studies have suggested a link between Yes-associated protein(YAP) and VC, but the underlying mechanisms remain poorly defin…
Co-transplantation of hucMSC-EVs with 250 islet equivalents significantly improved glycaemic control (p<0.01) and glucose toleranc…
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Introduction Organisms develop in chemically complex environments and have evolved to respond not only to their endogenous metabo-…
Consistently, immunofluorescence staining showed that the SESN2 signal was significantly increased in the SESN2-OE group and marke…
Introduction As a central energy status sensor in eukaryotic cells, AMPK orchestrates metabolic homeostasis through its heterotrim…
A statistically significant difference (P<0.05) between the pre- and post- exercise training period in the sedentary (SED) and exe…
A widely cited systematic review estimated an overall prevalence of 16.7% by combining autopsy and radiological series (14.4% and …
In bloodstream infections caused by P. aeruginosa, carbapenem resistance is an independent predictor of mortality, with a pooled a…
Although its pathophysiology is strongly associated with pancreatic β-cell dysfunction and altered metabolism in the liver, skelet…
We investigated the impact of the CDK4/6i palbociclib on mTORC1 signaling in TSC2-null human-derived cells, TSC2-deficient mouse e…
结论：The goal is not to force maximal ubiquitination or autophagy, but to restore the timing and selectivity with which healthy cell…
DHM increased mean lifespan to 21.78 ± 0.32, 22.45 ± 0.33, and 22.96 ± 0.34 days at 50, 100, and 200 μM, respectively, correspondi…