代谢干预与营养
NAD+ 前体、mTOR 抑制剂、GLP-1 受体激动剂、热量限制与限时进食。代谢是衰老最核心的驱动因素之一。
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To elucidate the active constituents and multi-target mechanisms underlying the therapeutic effects of Qianlie Shule granules (, Q…
Overall, these results confirm that RVG-EV-Mdivi-1 has good therapeutic effect for ischemic stroke, resulting in significantly imp…
Age-associated impairment of mitochondrial function contributes to reduced ATP production, increased oxidative stress, and disturb…
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A hook effect was observed with 3, which occurred at lower concentrations than seen for dBET1 (for example, at 10 μM for BRD4, but…
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Bioinformatic analysis of postmenopausal osteoporosis dataset GSE230665 identified VDAC1 as a core node linking mitophagy and oste…
Known-groups validity was supported as Sarco-HL scores differed by age groups (one-way ANOVA, p = 0.016), differences across age g…
Compared with the sham-operated control group, the proportion of cuproptosis increased significantly after ischemic injury ().；GO …
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We found that gamete-derived daughter cells lacked Pma2-GFP signal, which was fully retained on the plasma membrane of gametes for…
GeroScience 研究：芝麻木酚素 sesaminol 可减轻酒精诱导的中年小鼠结肠细胞衰老，机理上可能涉及 AhR–Nrf2 轴。
Of the 6,157 individuals followed up in the 9th wave, 1,752 were excluded for not undergoing the K-MMSE, 37 were excluded due to d…
However, how intranasal mesenchymal stem cell administration is associated with these cell type-specific responses remains incompl…
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Poorer family relationships, absence of hobbies or interests, less frequent outdoor activity, and the presence of retinopathy or a…
Interestingly, positive endosomes are not present in every cell or every animal and can vary from just a few to hundreds.；We found…
Genetic screens further show that different degraders share resistance genes associated with the ubiquitin system and drug efflux,…
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by progressive dyspnea, with high morbidity and …
The median number of emergency room visits within six months before or after the DRE was 0 (IQR: 0–1).；Marital status was signific…