时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
This review aims to address this knowledge gap by providing an updated, integrated perspective on the therapeutic potential of PBM in age-related disorders.
方法
In a major study conducted by Jeffery et al., thirty healthy participants underwent an oral glucose tolerance test (OGTT) with a 75 g glucose load.；Forty-five minutes prior to glucose administration, half of the participants were treated with 670 nm photobiomodulation at an intensity of 40 mW/cm2 during a 15-min session, applied over the upper back (800 cm2).；Notably, participants exposed to active PBM exhibited an overall reduction in blood glucose level of 7.3% compared to the sham group.
核心结论
Age-associated impairment of mitochondrial function contributes to reduced ATP production, increased oxidative stress, and disturbances in cellular homeostasis [, ].；These alterations are accompanied by elevated levels of intramyocellular lipids (IMCL), increased production of inflammatory mediators such as TLR2, TNF-α, and IL-1β, and chronic low-grade inflammation, all of which may promote insulin resistance and metabolic dysfunction [, ].；PBM, also known as low-level laser (or light) therapy (LLLT), is a non-invasive application of red to infrared light on body tissues. ‖ 结论：These are essential for the widespread clinical adoption of PBM.
局限
Future research should aim to define optimal treatment parameters.
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。
全文来源
PMC JATS 全文（正文 34,514 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Red Light Therapy and Mitochondrial Rejuvenation in Age-Related Disorders.
- 期刊与标识：Mol Neurobiol · PMID 42955214 · DOI 10.1007/s12035-026-06294-w
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