时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Cognitive impairment and metabolic abnormalities have emerged as major public health challenges globally, largely driven by population aging.；However, whether IR contributes to these sex differences in cognitive impairment remains unclear.；Therefore, in this study, we aimed to investigate the cross-sectional association between IR and cognitive impairment in community-dwelling Korean adults aged 54–86 years and explore the potential interactions of sex and age with insulin resistance.
方法
The Korean Genome and Epidemiology Study (KoGES) is a large-scale cohort project launched in 2001 by the National Institute of Health, the Korea Disease Control and Prevention Agency, to identify risk factors for common chronic diseases in Koreans ().；The community-based Ansan-Ansung cohort was established in 2001–2002 as part of the KoGES, enrolling 10,030 adults aged 40–69 years.；This study employed a cross-sectional design using data from the 9th-wave (2017–2018) survey of the ongoing KoGES Ansan-Ansung cohort.；This specific wave was selected because it represents the first major follow-up cycle of the specialized ‘Advanced Aging Study’ (baseline established in 2011–2014) where both multi-domain cognitive scores and fasting insulin/glucose levels were concurrently completed.
核心结论
Of the 6,157 individuals followed up in the 9th wave, 1,752 were excluded for not undergoing the K-MMSE, 37 were excluded due to dementia (36 previously diagnosed/treated and one with missing data), and 470 were excluded for missing fasting glucose or insulin data (required for HOMA-IR calculation).；Although high HOMA-IR (HHG) prevalence did not differ by sex (p = 0.21; ), women and older adults (≥65 years) exhibited a significantly higher prevalence of cognitive impairment (both p < 0.0001; ).；Higher depressive symptoms were associated with cognitive impairment (p < 0.0001; ), but not with HHG status (). ‖ 结论：In conclusion, this study suggests that sex may potentially interact with insulin resistance in its association with cognitive impairment, with IR as a key modifiable factor exclusively in women aged ≥65 years.
局限
This cross-sectional study demonstrated a significant association between IR and cognitive impairment, with sex acting as a primary interaction factor.；Furthermore, a cross-sectional analysis with a mean age of 48 years linked IR to poorer executive function, particularly in women ().；Given that muscle mass serves as a key protective factor for cognition () and shows significant sexual dimorphism (), the observed cognitive advantage likely reflects residual confounding by muscle mass.
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。设计 cross-sectional；最大样本量约 3,898。
全文来源
PMC JATS 全文（正文 31,888 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Interaction of sex and insulin resistance with cognitive impairment in community-dwelling middle-aged and older adults.
- 期刊与标识：Front Aging Neurosci · PMID 42964071 · DOI 10.3389/fnagi.2026.1889416
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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