时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
This question has distinct clinical relevance because it concerns the transition from early CKM risk states to advanced disease within a stage-based prevention framework.；Therefore, we examined the associations of baseline TyG-FI, cumulative TyG-FI, and two-wave TyG, FI, and TyG-FI patterns with incident CKM stage 4 and incident CKM stages 3–4 in a national cohort of Chinese middle-aged and older adults.
方法
Two-wave pattern clustering To characterize heterogeneity in change between Waves 1 and 3, we performed separate K-means analyses for TyG, FI, and TyG-FI.；Participants were retained in the selected cohort when individual baseline covariates were missing.；Individual covariate missingness was handled within the descriptive and statistical analyses.
核心结论
Sarcopenia and reduced physical activity may decrease skeletal-muscle glucose utilization and aggravate insulin resistance, while fatigue and functional Discussion In this national prospective cohort of adults with CKM stages 0–2, higher baseline TyG-FI was…；Frailty, in turn, reflects reduced physiological reserve across multiple systems; longitudinal and genetic-inference studies have linked frailty or changes in frailty with cardiovascular disease [ , ].；Associations of baseline and cumulative TyG-FI with CKM progression In fully adjusted models, higher baseline TyG-FI was associated with a greater hazard of incident CKM stage 4.；Two-wave analyses further showed that higher FI and TyG-FI classes, but not TyG classes alone, were strongly associated with transition to stage 4.
局限
Sarcopenia and reduced physical activity may decrease skeletal-muscle glucose utilization and aggravate insulin resistance, while fatigue and functional limitations may further reduce activity.；Together, these results suggest that combined metabolic–frailty burden and its changes capture clinically relevant heterogeneity in CKM progression beyond the information conveyed by a single metabolic measurement.
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：代谢—器官轴是干预安全性的主要约束面。 ｜ 价值分 1.0/5（★☆☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 32,619 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Associations of baseline levels, cumulative exposure, and two-wave patterns of the combined triglyceride-glucose index and frailty index with progression from cardiovascular-kidney-metabolic syndrome stages 0-2 to stages 3-4 and stage 4: a prospective cohort study from CHARLS.
- 期刊与标识：Cardiovascular diabetology · PMID 42958256 · DOI 10.1186/s12933-026-03411-w
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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