代谢干预与营养
NAD+ 前体、mTOR 抑制剂、GLP-1 受体激动剂、热量限制与限时进食。代谢是衰老最核心的驱动因素之一。
全部文章 · 第 10 页
← 返回专辑索引结论：Our findings demonstrate that the CKMS model effectively recapitulates a clinically relevant cardio–renal–metabolic state, char…
A global systematic review and meta-analysis published in 2014 estimated that, among individuals aged 45–85 years, the prevalence …
HPLC Method Validation] A reversed phase HPLC method was developed for trans-resveratrol (Inertsil ODS-3 column; acetonitrile/0.2%…
Understanding the mechanisms by which exercise activates autophagy and elicits metabolic benefits in the liver will provide import…
An immunohistochemical study of the lungs of mice of different ages was performed.；The results showed that with age, there is a pr…
新登记于 2026-10-27 的 NCT07898839：15 人、Phase 2，用 N-乙酰半胱氨酸、α-硫辛酸、烟酰胺核糖与二甲双胍缓释片组合加研究膳食，检验双硫死亡在胆汁疾病中的作用。
(n = 3 independent biological replicates) *p < 0.05; p < 0.01; *p < 0.001 (Rb1, ginsenoside Rb1; Young, EnSCs in the young female …
Quantitative analysis confirmed that argpyrimidine-positive areas were higher in the HFCS group than in the control group (mean sc…
Bacterial β-glucuronidases can deconjugate estrogen glucuronides in the intestine, facilitating reabsorption and potentially influ…
ROS, mitochondrial damage, LPS, and other microbial signals can activate NLRP3 inflammasomes, caspase-1, gasdermin D, and release …
The proteostasis network is a fundamental functional unit in biology that is essential for cellular health and has direct relevanc…
Particular emphasis is placed on sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) across the heart, liver, adipose tissue, skeletal muscle …
The aim of this study was to perform a quantitative ultrastructural assessment of the mitochondrial apparatus of rat hepatocytes d…
For BTBR mice, the two-way ANOVA interaction for time spent in chambers was significant (F (2, 69) = 3.3, p = 0.04). ‖ 结论：For the …
All values are presented as mean ± SEM (n = 3). *P < 0.05, P < 0.01, *P < 0.001, **P < 0.0001. ‖ 结论**：In conclusion, this study de…
At a constant chopper speed of 1400 rpm, extending the wet massing time from 3 to 7 min prompted a progressive and significant red…
At week 1, final body weight did not differ significantly between D1 and C1 (p = 0.710), whereas final fasting blood glucose was h…
GLP-1RA-induced weight loss is associated with 25–39% of total lost mass being lean tissue [10], as suggested by data published in…
Each data point represents an individual mouse (n = 3 per group). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant. ‖ 结论：T…
Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which amyloid-β (Aβ) deposition, abnormal tau pho…
Multifactorial Mechanisms of Skeletal Muscle Dysfunction in COPD Not all COPD patients develop skeletal muscle dysfunction; approx…
In stage 1, sham-operated (SO), OVX, and OVX + MOX rats were evaluated by micro-computed tomography (micro-CT) to assess bone mass…
Significant differences between treatment groups were observed for BMI (p < 0.001), fasting plasma glucose (p < 0.001), IRI (p < 0…
线粒体呼吸链抑制导致 NADH 还原应激与 NADPH 耗竭并存；只纠正 NADH/NAD+ 无法挽救原代人成纤维细胞增殖，而扩大 NADP(H) 池可逆转增殖停滞与衰老特征。