代谢干预与营养
NAD+ 前体、mTOR 抑制剂、GLP-1 受体激动剂、热量限制与限时进食。代谢是衰老最核心的驱动因素之一。
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← 返回专辑索引(A) Relative abundance of the six most abundant genera (>5%) across the three clusters.；Letters above the boxes indicate significa…
We used stringent criteria (|log2 fold change| > 1 and adjusted p < 0.05) to detect differentially expressed genes (DEGs).
Formulations prepared with higher lecithin content (225 mg; N4–N6) were found to have significantly higher EE% (84.2–93.0%) than t…
Building on the anticancer potential of oleuropein, a major olive tree (Olea europaea) metabolite, we evaluated a newly synthesise…
Statistical significance levels are denoted as follows: *p < 0.05 and p < 0.01.；Biological n = 3. j Normalized VSV mRNA levels in …
However, the mechanism by which NP promotes GN progression by inducing podocyte apoptosis remains unclear.；This study aimed to det…
Despite the relatively low 26.46% overall amino acid sequence identity between LMD-3 and human NCOA7 [25], the func- tional domain…
Overall, the mean age was 56.48 years, 46.0% of participants were male, 95.9% were White, and 90.8% resided in England.；Among the …
The proteostasis network is a fundamental functional unit in biology with relevance to many diseases.；Despite its importance, the …
Cellular senescence is itself heterogeneous: p16 and p21 expression, SA-β-gal activity, and SASP components vary across cell types…
Among boys, higher NA concentrations at baseline were associated with lower internalizing (β = −3.733, 95% CI: −6.686 to −0.779), …
Coefficients were exponentiated and reported as percentage differences with 95% CIs.；Their 95% percentile CIs were obtained by cas…
Forty-nine male SD rats were randomly divided into control group, sham-operated group, unilateral ureteral obstruction (UUO)-induc…
At the signaling level, peri- cyte contractility is regulated by multiple mediators, including platelet-derived growth factor-β (P…
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is a chronic metabolic disorder characterized by insulin resist…
ClinicalTrials.gov 记录于 2026-10-28 更新（仍为招募中）：验证 Vibegron 能否改善中老年肥胖者的能量代谢、心血管代谢风险因素与体能、认知功能。
There were no significant differences in sex distribution between the groups (p = 0.240).；44.34 years, p < 0.001), while the T1DM …
Concerning the molecular substrate of OPHSCCs, imbalances in signal transduction pathways are implicated in their onset and progre…
5-羟基-4-苯基呋喃-2(5H)-酮（FG1）延长线虫平均与最大寿命，转录组指向解毒与谷胱甘肽代谢；在 skn-1 缺陷株中延寿效应消失。
在线虫中，0.25 mg/mL 杨梅苷延长寿命并改善运动能力，未见生长/摄食/生殖毒性；机制指向 DAF-16 抗氧化响应与 SIR-2.1 相关的线粒体质量控制。
【摘要级】线粒体与生物能过程在大细胞外囊泡中富集，而在小细胞外囊泡中相互耗竭
把 [18F]FDG PET 与细胞组成估计、线粒体密度估计结合（并校正 RNA 含量与死后采样导致的差异基因表达），发现：线粒体分布与静息态内在能量需求强相关；而代谢与神经元组成的关系由感觉输入与线粒体稀疏的细轴突神经元驱动——刺激诱发的能量需求主要由不依赖…
串联出一条完整的「低温 → 代谢 → 长寿」因果轴。 （1）低温上调肌肉中的 CAT-4/GCH1，提高 BH2（BH4 的可转运储备形式）产量； （2）BH2 由肌肉产生并转运至远端组织（肠、神经元），在远端被 DHFR-1 转化为具有生物活性的 BH4 —…