代谢干预与营养
NAD+ 前体、mTOR 抑制剂、GLP-1 受体激动剂、热量限制与限时进食。代谢是衰老最核心的驱动因素之一。
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← 返回专辑索引GLP-1RA-induced weight loss is associated with 25–39% of total lost mass being lean tissue [10], as suggested by data published in…
Each data point represents an individual mouse (n = 3 per group). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant. ‖ 结论：T…
Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which amyloid-β (Aβ) deposition, abnormal tau pho…
Multifactorial Mechanisms of Skeletal Muscle Dysfunction in COPD Not all COPD patients develop skeletal muscle dysfunction; approx…
In stage 1, sham-operated (SO), OVX, and OVX + MOX rats were evaluated by micro-computed tomography (micro-CT) to assess bone mass…
Significant differences between treatment groups were observed for BMI (p < 0.001), fasting plasma glucose (p < 0.001), IRI (p < 0…
线粒体呼吸链抑制导致 NADH 还原应激与 NADPH 耗竭并存；只纠正 NADH/NAD+ 无法挽救原代人成纤维细胞增殖，而扩大 NADP(H) 池可逆转增殖停滞与衰老特征。
(A) Relative abundance of the six most abundant genera (>5%) across the three clusters.；Letters above the boxes indicate significa…
We used stringent criteria (|log2 fold change| > 1 and adjusted p < 0.05) to detect differentially expressed genes (DEGs).
Formulations prepared with higher lecithin content (225 mg; N4–N6) were found to have significantly higher EE% (84.2–93.0%) than t…
Building on the anticancer potential of oleuropein, a major olive tree (Olea europaea) metabolite, we evaluated a newly synthesise…
Statistical significance levels are denoted as follows: *p < 0.05 and p < 0.01.；Biological n = 3. j Normalized VSV mRNA levels in …
However, the mechanism by which NP promotes GN progression by inducing podocyte apoptosis remains unclear.；This study aimed to det…
Despite the relatively low 26.46% overall amino acid sequence identity between LMD-3 and human NCOA7 [25], the func- tional domain…
Overall, the mean age was 56.48 years, 46.0% of participants were male, 95.9% were White, and 90.8% resided in England.；Among the …
The proteostasis network is a fundamental functional unit in biology with relevance to many diseases.；Despite its importance, the …
Cellular senescence is itself heterogeneous: p16 and p21 expression, SA-β-gal activity, and SASP components vary across cell types…
Among boys, higher NA concentrations at baseline were associated with lower internalizing (β = −3.733, 95% CI: −6.686 to −0.779), …
Coefficients were exponentiated and reported as percentage differences with 95% CIs.；Their 95% percentile CIs were obtained by cas…
Forty-nine male SD rats were randomly divided into control group, sham-operated group, unilateral ureteral obstruction (UUO)-induc…
At the signaling level, peri- cyte contractility is regulated by multiple mediators, including platelet-derived growth factor-β (P…
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is a chronic metabolic disorder characterized by insulin resist…
ClinicalTrials.gov 记录于 2026-10-28 更新（仍为招募中）：验证 Vibegron 能否改善中老年肥胖者的能量代谢、心血管代谢风险因素与体能、认知功能。
There were no significant differences in sex distribution between the groups (p = 0.240).；44.34 years, p < 0.001), while the T1DM …