代谢干预与营养

A statistically significant difference (P<0.05) between the pre- and post- exercise training period in the sedentary (SED) and exe…

A widely cited systematic review estimated an overall prevalence of 16.7% by combining autopsy and radiological series (14.4% and …

In bloodstream infections caused by P. aeruginosa, carbapenem resistance is an independent predictor of mortality, with a pooled a…

Although its pathophysiology is strongly associated with pancreatic β-cell dysfunction and altered metabolism in the liver, skelet…

We investigated the impact of the CDK4/6i palbociclib on mTORC1 signaling in TSC2-null human-derived cells, TSC2-deficient mouse e…

结论：The goal is not to force maximal ubiquitination or autophagy, but to restore the timing and selectivity with which healthy cell…

DHM increased mean lifespan to 21.78 ± 0.32, 22.45 ± 0.33, and 22.96 ± 0.34 days at 50, 100, and 200 μM, respectively, correspondi…

结论：Our findings demonstrate that the CKMS model effectively recapitulates a clinically relevant cardio–renal–metabolic state, char…

A global systematic review and meta-analysis published in 2014 estimated that, among individuals aged 45–85 years, the prevalence …

HPLC Method Validation] A reversed phase HPLC method was developed for trans-resveratrol (Inertsil ODS-3 column; acetonitrile/0.2%…

Understanding the mechanisms by which exercise activates autophagy and elicits metabolic benefits in the liver will provide import…

An immunohistochemical study of the lungs of mice of different ages was performed.；The results showed that with age, there is a pr…

新登记于 2026-10-27 的 NCT07898839：15 人、Phase 2，用 N-乙酰半胱氨酸、α-硫辛酸、烟酰胺核糖与二甲双胍缓释片组合加研究膳食，检验双硫死亡在胆汁疾病中的作用。

(n = 3 independent biological replicates) *p < 0.05; p < 0.01; *p < 0.001 (Rb1, ginsenoside Rb1; Young, EnSCs in the young female …

Quantitative analysis confirmed that argpyrimidine-positive areas were higher in the HFCS group than in the control group (mean sc…

Bacterial β-glucuronidases can deconjugate estrogen glucuronides in the intestine, facilitating reabsorption and potentially influ…

ROS, mitochondrial damage, LPS, and other microbial signals can activate NLRP3 inflammasomes, caspase-1, gasdermin D, and release …

The proteostasis network is a fundamental functional unit in biology that is essential for cellular health and has direct relevanc…

Particular emphasis is placed on sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) across the heart, liver, adipose tissue, skeletal muscle …

The aim of this study was to perform a quantitative ultrastructural assessment of the mitochondrial apparatus of rat hepatocytes d…

For BTBR mice, the two-way ANOVA interaction for time spent in chambers was significant (F (2, 69) = 3.3, p = 0.04). ‖ 结论：For the …

All values are presented as mean ± SEM (n = 3). *P < 0.05, P < 0.01, *P < 0.001, **P < 0.0001. ‖ 结论**：In conclusion, this study de…

At a constant chopper speed of 1400 rpm, extending the wet massing time from 3 to 7 min prompted a progressive and significant red…

At week 1, final body weight did not differ significantly between D1 and C1 (p = 0.710), whereas final fasting blood glucose was h…