同行评议人体研究

Mediation analysis tested whether AD pathology and brain structure mediated the association between p62/SQSTM1 and cognition.ResultsElevated CSF p62/S…

For all analyses, APOE genotype was categorized into three groups: APOE2 (ε2/ε3, N = 39), APOE3 (ε3/ε3, N = 171), or APOE4 (ε3/ε4 or ε4/ε4, N = 72) (T…

To investigate CMV-associated immune signatures, we established two independent healthy adult cohorts (Cohort 1 and Cohort 5), stratified by CMV seros…

Results: Fall risk screening positivity did not differ significantly between groups (69% buprenorphine vs 58% other opioids; P = .179).；Conclusion: Th…

Borderline personality disorder (BPD) is a severe mental illness associated with emotional and functional impairment, elevated suicide risk, and high …

A positive change in MTV of ≥6.270 between EOT PET and baseline (ΔMTV eot−b ) was also significantly associated with failure to achieve a CR (OR, 88.2…

The two-year field experiment (2023-2025) evaluated the effects of colored shade nets (red, yellow, green, and blue) with varying shading intensities …

Using a significance threshold of false discovery rate (FDR) < 0.05, we identified 2977 genes whose expression decreased with age and 1609 genes whose…

When evaluated against CA, the KDM approach demonstrated superior predictive precision, achieving a higher coefficient of determination (R2=0.597) and…

All MNV eyes were associated with neovascular age-related macular degeneration; no myopic, pachychoroid-related, or other secondary MNV etiologies wer…

Acute myeloid leukemia (AML) arises from the malignant transformation of hematopoietic stem or progenitor cells and is defined by the clonal expansion…

Patients referred for auricular prosthetic rehabilitation were managed through a standardized multidisciplinary team including maxillofacial and/or ot…

（未抽取到结果句）

There were no significant differences between the GA secondary to AMD and control groups in terms of age (72.9 ± 13.1 vs. 74.2 ± 9.1 years, p = 0.539)…

We identified a quinazolinone derivative as an initial hit with an IC50 of 124 nM (95% C.I. 90–160 nM) (Fig. ).；Maintaining the quinazolinone moiety w…

However, increased longevity leads to substantial increases in background health system costs (numbers underlying these figures are provided in Suppor…

In terms of educational attainment, 66.2% could not read or write, 34.2% did not complete primary school, and 2.1% completed 12 years of schooling.；Th…

The data were split based on participant age for exploratory analyses, and those who were 65 years of age or older formed the older adult group (N = 3…

Arrayed validation identifies perturbation of Dusp5 and Zfp219 as the strongest candidates for improved tumor control, and these findings extend validat…

No statistically significant differences in immunoglobulin concentrations were identified among ethnic groups.；However, the capacity to detect potenti…

Of 6721 patients with cancer who received palliative care consultations, 6151 were included in the analysis after excluding those with consultations p…

E117 Age-Dependent Reversal of Sex Differences in Severe Long-Term Care Dependency: A Six-Year Analysis of Integrated Healthcare and Long-Term Care Da…

The median age was 48.0 years (IQR, 34.3–63.5; range, 20–84), and 19 patients (24.4%) were aged 65 years or older.；CYP2D6 reduced/no‐function allele c…

Limited real-world guidance exists on managing advanced NSCLC in patients with comorbidities and frailty.；To address this knowledge gap, a multidiscip…