时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
Studies have shown that VF may be linked with metabolic dysregulation including glucose intolerance and insulin resistance, whereas SF may actually have a protective role.；In addition to body composition, functional quantitative biomarkers such as metabolic tumor volume (MTV) have been found to be prognostic in HL.
方法
Methods We conducted a single-center, retrospective study reviewing adult patients (aged ≥18 years) with histologically confirmed stage III/IV ASHL who received frontline treatment with BV-AVD between 2020 and 2023.；Toxicity data were obtained from chart review and, if not specifically noted, were inferred from patient notes and physical examinations and graded according to Common Terminology Criteria for Adverse Events version 5.0 guidelines.；Manual segmentation was performed by a single, experienced nuclear medicine radiologist using MIM Maestro (MIM Software, Cleveland, OH).
核心结论
A positive change in MTV of ≥6.270 between EOT PET and baseline (ΔMTV eot−b ) was also significantly associated with failure to achieve a CR (OR, 88.22; 95% CI, 2.26 to infinite; P = .017), as shown in .；Patients who maintained their SM:VF ratio from baseline to EOT were significantly more likely to achieve a CR, suggesting that either an increase in SM or decrease in VF may be driving clinical benefit.；Likewise, a change in the SF:VF ratio of at least −10.262 between EOT PET and iPET increased the risk of a PFS event 7.60-fold (HR, 7.60; 95% CI, 1.25-46.12; P = .028; ). result in greater off-target AEs.；Univariable analyses showed that patients with measurable (positive) MTV at EOT were significantly more likely to not achieve a CR than those with MTV negativity (OR, 62.00; 95% CI, 4.53-848.68; P = .002).
局限
However, given that there was minimal change in the SM:VF ratios from iPET to EOT PET, the cohort included only 6 non-CR events, and the data had very wide CIs, these results should be interpreted with caution.；Additionally, given that positive MTV at the EOT PET and ΔMTV from iPET to EOT PET were significant predictors of PFS, future studies should examine strategies for early intervention in this patient population.
对本项目的价值
临床前机制证据，需评估物种外推与剂量可行性：与肿瘤交叉参考：衰老机制在肿瘤治疗抵抗 / 毒性中的双向作用。 ｜ 价值分 0.5/5（★☆☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 28,057 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Impact of body composition on toxicity and response in patients with advanced-stage Hodgkin lymphoma treated with BV-AVD.
- 期刊与标识：Blood neoplasia · PMID 42959917 · DOI 10.1016/j.bneo.2026.100303
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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