时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
Given the high prevalence of malnutrition among oncology patients and its adverse consequences, European Society of Clinical Nutritional and Metabolism (ESPEN) guidelines recommend early nutritional screening to detect both established…；Despite the availability of various diagnostic tools, the
方法
Data were stored in a database using the SPSS 29.0.1.1 statistical software package (SPSS Inc., Chicago, IL, United States) under an official license from University of Valladolid.；Finally, the collected data underwent a descriptive statistical analysis to assess the prevalence of malnutrition and compare the different morphofunctional techniques.；To ensure methodological robustness and transparency, collinearity diagnostics were performed prior to modeling by calculating the Variance Inflation Factor (VIF).
核心结论
A lower percentage of Mi was linked to a higher risk of death and shorter survival, whereas higher FATi alone was not significantly associated with mortality; however, the coexistence of low Mi and high FATi was associated with increased mortality.；In our cohort, increased rectus femoris thickness and larger rectus femoris area were independently associated with reduced mortality.；Being below the cut-off point for the percentage of muscle mass (Mi) in the ROI was associated with an increased risk of mortality, whereas this was not observed for the percentage of fat mass (FATi) ( ).；Higher muscle mass measured by muscle ultrasound was associated with a more favorable prognosis against mortality in cancer patients, while patients with low muscle quality are associated with increased mortality.
局限
The intraclass correlation coefficients were 0.912 (95% CI: 0.872–0.940) for subcutaneous fat thickness, 0.960 (95% CI: 0.941–0.973) for rectus femoris muscle thickness, and 0.995 (95% CI: 0.993–0.997) for rectus femoris cross-sectional…；Despite the availability of various diagnostic tools, the objective assessment of malnutrition is hindered by intrinsic limitations such as interobserver variability, cost, and lack of validation ( ).
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：与肿瘤交叉参考：衰老机制在肿瘤治疗抵抗 / 毒性中的双向作用。 ｜ 价值分 0.5/5（★☆☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 44,988 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Novel AI-derived muscle ultrasound biomarkers linking nutritional status and prognosis in cancer patients.
- 期刊与标识：Frontiers in nutrition · PMID 42953640 · DOI 10.3389/fnut.2026.1961328
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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