时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
INTRODUCTION Rapid population aging in Japan has emerged as a major public health challenge, accompanied by increasing disease burden from chronic conditions and a growing number of older adults requiring long-term care (1).；However, because medical and long-term care data are often fragmented owing to institutional and technical barriers, only a limited number of studies have quantitatively examined age-dependent changes in long-term care demand and its concentration among the oldest-old women (aged ≥85 years), using large-scale real-world data integrating medical claims and long-term care certification records.；The aim of this study was to comprehensively characterize the dynamics of population structure, disease burden, and long-term care demand among older adults.
方法
We conducted a repeated cross-sectional study using integrated medical claims and long-term care certification data from approximately 400,000 adults aged ≥65 years in Kobe City, Japan, between fiscal years 2017 and 2022.；Women aged ≥85 years exhibited substantially elevated odds of severe care dependency (OR ≈46) compared with women aged 65–69 years.；Significant age-by-sex interactions were observed, and the pattern of severe care dependency shifted from male predominance among younger-old adults (aged 65–74 years) to female predominance among older-old adults (aged ≥80 years), indicating that long-term care needs are increasingly concentrated among the oldest-old women.；In the present study, we analyzed an anonymized individual-level database integrating medical claims and long-term care certification records for approximately 400,000 residents aged 65 years and older who were enrolled
核心结论
E117 Age-Dependent Reversal of Sex Differences in Severe Long-Term Care Dependency: A Six-Year Analysis of Integrated Healthcare and Long-Term Care Data MICHIYO KAWAI1,2 and YOICHI KUREBAYASHI1, * 1 Department of Artificial Intelligence and Digital Health Sciences, Kobe University Graduate School of Medicine, Kobe, Japan; 2 Kobe University Graduate School of Science, Technology and Innovation, Kobe, Japan *Corresponding author Received June 30, 2026/Accepted July 24, 2026 Keywords: Population aging, Disease burden, Long-term care dependency, Sex differences, Healthy life expectancy Population aging has increased the burden of chronic diseases and long-term care needs worldwide.；Although the overall study population remained stable, the proportion of individuals aged ≥85 years, particularly women, increased over time. ‖ 结论：These findings provide important epidemiological evidence for understanding the structure of long-term care demand in aging societies and may contribute to risk stratification and the development of preventive strategies aimed at extending healthy life expectancy.
局限
We conducted a repeated cross-sectional study using integrated medical claims and long-term care certification data from approximately 400,000 adults aged ≥65 years in Kobe City, Japan, between fiscal years 2017 and 2022.；However, because the present study was observational in nature, the relative contributions of these factors could not be directly evaluated.；Further studies are therefore warranted to elucidate the mechanisms underlying this phenomenon.
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。设计 cross-sectional；最大样本量约 400,000。
全文来源
出版商 OA PDF（正文 41,710 字符，已过 DOI 逐字 / 标题指纹归属校验）
原文题录
- 英文标题：Age-Dependent Reversal of Sex Differences in Severe Long-Term Care Dependency: A Six-Year Analysis of Integrated Healthcare and Long-Term Care Data.
- 期刊与标识：Kobe J Med Sci · PMID 42950852 · DOI 10.24546/0100505678
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。