时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the trajectory of immune aging varies widely between individuals [], leading to differences in immune health, vaccine efficacy, and therapeutic responses [–].
方法
To investigate CMV-associated immune signatures, we established two independent healthy adult cohorts (Cohort 1 and Cohort 5), stratified by CMV serostatus and profiled using scRNA-seq, scTCR-seq, and/or flow cytometry (Fig. a).；Cohort 1 was used to uncover CMV-associated cell frequency signatures, whereas Cohort 5 was used to uncover CMV-associated TCR signatures.；To assess the generalizability of these signatures (Fig. a), we additionally analysed data from four publicly available cohorts (Fig. a).；Across all six cohorts, participants were free from confounding autoimmune diseases, were not undergoing treatments that might influence immune function and composition (e.g., immunotherapy) and had not been recently vaccinated prior to blood collection.
核心结论
To investigate CMV-associated immune signatures, we established two independent healthy adult cohorts (Cohort 1 and Cohort 5), stratified by CMV serostatus and profiled using scRNA-seq, scTCR-seq, and/or flow cytometry (Fig. a).；CMV(+) and CMV(-) groups were comparable in age (p = 0.90), body mass index (BMI; median 27.8, p = 0.51), and frailty index [] (median 0.085, p = 0.50) (Additional file 1: Figure S1a, Additional file 2: Table S1).；CMV(+) and CMV(-) groups were comparable in age (p = 0.39), body mass index (BMI; median 26.3, p = 0.90), and frailty index [] (median 0.064, p = 0.97) (Additional file 2: Table S1). ‖ 结论：Furthermore, CMVerify successfully captured a seroconversion event, highlighting rapid (within months) PBMC compositional shifts induced by primary CMV infection.
局限
Future studies will be essential to understand how Th1 cells contribute to latent CMV responses, e.g., by helping cytotoxic lymphocyte proliferation [] and/or stimulating CMV-specific antibody formation via ABCs.；Beyond database limitations, additional mechanisms, such as clonal responses to other chronic or prior infections, may also contribute to the expansion of unannotated clonotypes.；Despite these limitations, our study provides valuable and novel insights into the systemic effects of latent CMV across multiple cohorts and age groups.
对本项目的价值
★☆☆☆☆ 炎症衰老是几乎所有慢性老年病的公共通路，也是最有希望做「抗炎但保留免疫」解耦的靶点。设计 single-cell。
全文来源
PMC JATS 全文（正文 64,642 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells.
- 期刊与标识：Genome Biol · PMID 42958310 · DOI 10.1186/s13059-026-04198-5
A 级证据分级：A 级（同行评议人体研究）
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