时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Establishing reliable pediatric RIs remains challenging because of the difficulty of recruiting large numbers of healthy children across different age groups.；To address these challenges, the Clinical and Laboratory Standards Institute (CLSI) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommend rigorous population selection and robust statistical approaches for RI derivation and validation ().
方法
The study was approved by the Research Ethics Committees of the Federal University of São Paulo (UNIFESP) under approval numbers 3.340.392 and 3.499.511, in accordance with the principles of the Declaration of Helsinki and the regulations of the Brazilian Ministry of Health.；A total of 2,911 clinically healthy infants, children, and adolescents aged 1 month to 17 years were included.；Participants were recruited from well-child outpatient clinics at UNIFESP and the Campinas Municipal Pediatric Outpatient Clinic.；Additionally, children undergoing routine preoperative laboratory evaluation before minor elective surgical procedures at these institutions were enrolled.
核心结论
No statistically significant differences in immunoglobulin concentrations were identified among ethnic groups.；However, the capacity to detect potential variations within the Black (n = 46) and Asian (n = 9) subgroups was limited by the relatively small sample sizes, which reduced the overall statistical power for these specific comparisons. – depict the age-related distributions of serum IgG, IgA, and IgM concentrations derived from quantile regression analysis.；Collectively, these findings characterize the age-dependent evolution of serum immunoglobulin concentrations in the Brazilian pediatric population. ‖ 结论：The proposed reference curves constitute a robust, biologically grounded, and clinically applicable standard for interpreting serum IgG, IgA, and IgM levels in Brazilian children, with particularly relevant implications for the early diagnosis of primary immunodeficiencies and for monitoring humoral immunity throughout childhood.
局限
Several limitations should be considered when interpreting these findings.；First, the cross-sectional design did not allow longitudinal assessment of individual immune maturation trajectories.；The corresponding 95% confidence intervals account for the increased uncertainty associated with these sample sizes; therefore, the extreme percentiles (P2.5 and P97.5) in these age groups should be interpreted with caution.
对本项目的价值
★☆☆☆☆ 炎症衰老是几乎所有慢性老年病的公共通路，也是最有希望做「抗炎但保留免疫」解耦的靶点。最大样本量约 2,911。
全文来源
PMC JATS 全文（正文 22,886 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Age-specific reference intervals for serum IgG, IgA, and IgM in healthy Brazilian children and adolescents.
- 期刊与标识：Front Immunol · PMID 42947674 · DOI 10.3389/fimmu.2026.1969584
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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