时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the literature also recommends that planning for specific support should begin from the age of 45 onwards (; ; ).；The increased longevity of people with ID is a welcome and relevant demographic shift that comprises new challenges in terms of support and care ().
方法
This project was approved by the Ethics Committee of the Health Sciences Research Unit: Nursing (Opinion No.；Each participating organization identified clients who met the inclusion criteria: (i) having a diagnosis of ID and (ii) being aged ≥45 years.；The final analytical sample comprised 234 individuals with intellectual disability aged 45 years or older.；The message included information for the participants, with a detailed description of the study, objectives and instructions on how to access and complete the questionnaire; a link to the online questionnaire (hosted on the LimeSurvey platform); a PDF version of the questionnaire for prior review; templates for the informed consent forms (for the respondent mediator, the legal representative of the person with ID aged ≥ 45 years, and the person with ID); and the research team's contacts.
核心结论
In terms of educational attainment, 66.2% could not read or write, 34.2% did not complete primary school, and 2.1% completed 12 years of schooling.；The majority (89.3%) were pensioners or retired.；In addition, 71 participants (30.3%) reported other chronic conditions (lasting more than 3 months): high blood pressure (n = 17; 23.94%), heart problems (n = 11; 15.49%), type 2 diabetes (n = 11; 15.49%), cancer (n = 6; 8.45%), respiratory problems (n = 5; 7.04%), high cholesterol (n = 5; 7.04%), obesity or being overweight (n = 5; 7.04%), thyroid problems (n = 4; 5.63%), anemia (n = 3; 4.23%), lupus (n = 1; 1.41%), rheumatoid arthritis (n = 1; 1.41%), constipation (n = 1; 1.41%), asthma (n = 1; 1.41%), arthritis (n = 1; 1.41%), seizures (n = 1; 1.41%), kidney failure (n = 1; 1.41%) and osteoporosis (n = 1; 1.41%). ‖ 结论：In addition, the low response rate, together with the lack of organization recruitment data, limited the assessment of potential selection bias, cluster sizes, participant distribution across organizations, organizational-level representativeness, and clustering by organization or mediator.
局限
These findings are consistent with other studies (e.g., ), reinforcing the lack of access to paid employment and to income of their own.；Future studies could validate these instruments for the Portuguese older population with ID to help more accurately identify the onset of frailty in these persons, thereby enabling appropriate healthy aging interventions.；However, this association should be interpreted with caution, since the CFS includes information on functionality, mobility, cognition, and dependence.
对本项目的价值
★☆☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。设计 cross-sectional。
全文来源
PMC JATS 全文（正文 38,856 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Aging with intellectual disabilities: a study in Portugal about clinical conditions, functionality, and frailty.
- 期刊与标识：Front Hum Neurosci · PMID 42953056 · DOI 10.3389/fnhum.2026.1952261
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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