生命历程与发育编程
早期生命经历、发育编程、早衰症与健康不平等。衰老并非始于晚年，胎盘与生命早期已埋下伏笔。
全部文章 · 第 12 页
← 返回专辑索引Because hemocytes are in contact with the hemolymph throughout life, they register the nutritional state of the organism through c…
In osteoblastic and pre-osteoblastic cells, LF reduces apoptosis induced by stress conditions via Wnt5a-dependent activation of cA…
Introduction Laminins are heterotrimeric glycoproteins assembled from five α chains (α1–α5), three β chains (β1–β3), and three γ c…
Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls a…
Searches were conducted in PubMed, CINAHL, and Scopus.；Randomised controlled trials explicitly defining frailty were eligible.；Two…
However, persistent nutritional restraint could eventually become disadvantageous if nutritional and physiological reserves become…
NHANES 13,379 名中老年人，四项指标（AL、HD、PhenoAgeAccel、KDM Accel）一致显示中等活动量的效应最优；高活动量在主要模型中均无显著关联，且跨年龄组与 KDM Accel 呈一致正相关。
UK Biobank 38,577 名基线无衰弱者，中位随访 9.37 年、1,024 例新发衰弱；DHA 每五分位间距 HR 0.82（95%CI 0.69–0.97），而非 DHA 的 n-3 与总 n-3 均不显著。
In South America, Brazil was consistently classified in low–low clusters for AHEI, with a median local Moran’s I of 0.92 (95% UI 0…
We analysed clinical data from 69 patients aged 65–83 years (median age 74 years), representing 2.9% (69/2378) of all new STIs dia…
Transfected cells were treated with cambinol (100 µM), vehicle control (VC), and VC containing 1% DMSO to match the DMSO concentra…
To formally assess bioequivalence, 90% confidence intervals (CIs) were calculated for the geometric mean ratios (Test/Reference) o…
The study duration averaged 70 months (SD 5.38) with a sample mean age of 62 years (9.83) and 60.64% women.；There was evidence of …
SOY reduced final BW in the βKO mice by ~17%, which was not evident in the WT (0%) or αKO (6%) mice.；This associated with a trend …
This study aimed to examine age- and sex-related differences in NWES-derived swallowing-related time metrics and their relationshi…
Telomerase activity is usually low or undetectable in most normal somatic cells, whereas it is detected in most human cancers (up …
Genotyping of the hTERT-MNS16A variant was performed through polymerase chain reaction (PCR), while relative LTL was measured usin…
用 BMI、HbA1c、总胆固醇、ALT、eGFR、收缩压、白细胞计数七项指标做非参数排序，NHANES 1988–2018 显示健康分布显著恶化且集中在下尾；反事实分解显示约三分之一可归因于人口老龄化与族裔结构变化。
Data are presented as means ± SEM with individual values shown. *P<0.001, P<0.0001.；Data are presented as means ± SEM. P<0.0001. ‖…
Gut Microbiome Analysis] After a rigorous quality check and preprocessing, which removed about 20% of the sequences, all sequences…
In our study, the highest MDA and lowest GSH levels in hippocampal tissue were obtained in CPZ group (Group 3) and CPZ group fed a…
Carnyx Therapeutics 公布 CNYX-005 临床前数据：老年大鼠总睡眠时间较对照增加约 1.5~2 小时，主要来自 NREM 睡眠；10-27 宣布进入 IND-enabling 开发。
Dog Aging Project 首批生存分析：小型犬中位寿命 14 年、巨型纯种犬不足 10 年；纯种犬比混血略短；地区差异与人类死亡率分布显著正相关。