生命历程与发育编程
早期生命经历、发育编程、早衰症与健康不平等。衰老并非始于晚年，胎盘与生命早期已埋下伏笔。
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Higher total serum IgG levels have been associated with protection from cardiovascular events in ASCOT (Anglo-Scandinavian Cardiac…
Almost all students worked with older adults in their profession or job (98.6%) or visited a nursing home or a geriatric clinic (8…
To evaluate, using microtensile bond strength (μTBS) testing and in situ zymography, the effects of an experimental zirconium oxyn…
Efferocytosis is a specialized phagocytic program for apoptotic cells that is often immunologically silent or tolerogenic and enga…
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In terms of education, 22.50% had primary school education or below, 34.48% had middle school education, 34.80% had a high school …
Consistent with our previous sequencing data identifying miR-543 as the most significantly dysregulated miRNA in female FGR placen…
在 NHANES 1999–2000 与 2001–2002 周期的分析中，蛋白质摄入以 g/kg/天表示，生物学年龄（BA）用 端粒长度（TL）、AnthropoAge、PhenoAge 与 Klemera-Doubal 法（KDM）估计
在酵母中证明翻译延伸因子 eIF5A 为热应激快速反应所必需，缺失后核糖体停滞于热诱导 mRNA、Hsp70 Ssa1 与 Hsp12 等 chaperone 合成下降并出现蛋白聚集；摘要未给定量。
比较年轻红细胞（YRBC）与年老红细胞（ORBC）对流体剪切的响应：只有在缺钙条件下，ORBC 表现出明显的剪切后肿胀，且只有部分能被 ATP 依赖机制恢复；钙的存在维持了容量稳态，揭示出一类钙敏感的代偿调控机制是代谢受损 ORBC 维持体
6 周双盲随机活性安慰剂对照先导试验（最终 n=20）中，PTx800 组探诊出血降低 100%（出血位点完全消退），活性安慰剂组降低 82%，qPCR 显示 Pg、Tf、Td 等红色复合体病原显著减少。
利用种子甲虫 200 余代实验演化（分别向短寿与长寿方向选择，寿命近乎翻倍），全基因组重测序显示：短/长寿系强烈分化（global FST = 0.41），700 多个基因有一致的分化选择信号；更关键的是两系在大量拷贝数变异（CNV）区域上
摘要未给定量（无 IC50、浓度或效应量数值） → 待补全文；定性而言，hesperadin（系列 A）与 GNF-7（系列 B）两系列抑制剂均能抑制 LRRK2 激酶活性，但仅 B 系列增强结构域间异源磷酸化位点的磷酸化，并恢复磷酸化受抑
摘要未给定量 → 待补全文；定性上，衰老与内源性透明质酸（HA）酶解耗竭均显著降低小鼠肌腱 HA 含量与弹性、黏弹性及总胶原纤维回缩（反映纤维滑动减弱），而低分子量甲基丙烯酰化 HA 经光交联驻留后可把回缩恢复至接近成年对照水平。
cryo-EM 解析体外组装的人 C9orf72 晚期翻译起始复合物达 3.2 Å 分辨率、细胞裂解液纯化的近天然复合物达 3.5 Å；RAN 翻译主要起始于 G4C2 重复上游 24 个核苷酸处的近同义 CUG 密码子。
在德国 3 家三级心脏瓣膜中心前瞻性入组成人中度钙化三尖瓣狭窄患者，每年随访最长 5 年，主要终点为进展至重度狭窄或置换的时间。
In the primary cohort (N = 42), the older adults were less accurate overall, F(1, 40) = 9.54, p = 0.004, η2G = 0.156, and accuracy…
The union of the five original exports retrieved all 33 final included reports (100%), although no single database was complete.；O…
Work in Drosophila establishes that insulin signaling is allatotropic - it stimulates the production and secretion of JH from the …
A total of 2,969 participants were included in the present study, with a mean age of 66.61 years; 1,495 (51%) were men and 1,474 (…
2,006 名 ≥65 岁急性老年医学科住院患者，6 个月死亡率 22%；CFS 每增加 1 分死亡风险升 50%，且衰弱越重、加权疾病负担的预后贡献被削弱（交互 p=0.011）。
A DHEA-induced murine PCOS model was generated for in vivo experiments.；Serum hormonal profiles and insulin sensitivity were asses…