时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Despite the growing appreciation of this crosstalk, a comprehensive synthesis of the molecular mechanisms governing the reciprocal regulation between phagocytosis and cGAS-STING signaling remains lacking.；The hierarchical relationship—whether phagocytosis acts upstream to enable STING activation, or STING signaling regulates phagocytic function—is highly context-dependent, varying with cell type, stimulus, and disease setting.
方法
Zhao et al further showed that Cmpk2 protects against acute lung injury by sustaining STING expression in neutrophils, thereby maintaining their phagocytic capacity; STING inhibition with C176 impaired bacterial clearance.；While these recruited phagocytes alone exhibit limited phagocytic activity due to the CD47-SIRPα “don’t eat me” signal on tumor cells, combining cGAMP with anti-CD47 antibody blockade significantly enhances phagocytosis of tumor cells, leading to improved antigen presentation and robust CD8⁺ T cell priming.；Most of the mechanistic and therapeutic studies discussed here are preclinical, including cell-based assays, mouse models, and ex vivo human systems.
核心结论
Efferocytosis is a specialized phagocytic program for apoptotic cells that is often immunologically silent or tolerogenic and engages phosphatidylserine receptors and MerTK/TIM-4/Stabilin-2/BAI-1 pathways., LC3-associated phagocytosis (LAP) and conjugation of ATG16L1 to single membranes (CASM) are not distinct uptake routes; they are LC3-lipidation programs associated with single-membrane phagosomes and require components such as Rubicon, NADPH oxidase, V-ATPase, and ATG16L1, and they can either promote cargo degradation or permit cytosolic leakage.；Antigen uptake, nanoparticle internalization, and autophagic clearance are related but non-interchangeable processes; they are considered here only when they directly deliver cGAS or STING ligands or modulate phagocytic cargo handling. ‖ 结论：The intricate and bidirectional interplay between the cGAS-STING signaling pathway and phagocytosis represents a fundamental regulatory axis in innate immunity, with profound implications for health and disease.
局限
Crucially, whether this crosstalk is beneficial or detrimental is not fixed and cannot be generalized across diseases.；Looking forward, future research should prioritize several key directions to translate these fundamental insights into clinical impact.；Future work should therefore use cell-type-specific and temporally controlled in vivo models, define the molecular bridges and checkpoints that link STING to phagocytosis, and test combination strategies in rationally selected disease contexts.
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。
全文来源
PMC JATS 全文（正文 100,813 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The Tango of cGAS-STING and Phagocytosis in Disease: From Molecular Mechanisms to Pharmacological Targeting.
- 期刊与标识：Drug Des Devel Ther · PMID 42953815 · DOI 10.2147/dddt.s650641
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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