同行评议人体研究

We delimited four subtypes, which two exhibited higher risk for conversion to AD.

In participants with MASLD, a decrease in handgrip strength was significantly associated with an increased risk of CVD [ ].；For instance, data from th…

Elevated proliferation was observed in cisplatin-exposed OC cells upon M2d TAMs treatment or ApoE overexpression, which further verified the developme…

Sortilin 1 (SORT1) may facilitate CES1 lysosomal targeting, while a cytosolic pool of SORT1 has been reported to undergo chaperone-mediated autophagy …

The results indicate that LTCI leads to significant improvements in physical health for both groups.；By contrast, its effects on the CESD-10 depressio…

Here we show that these relaxation-protected modes follow directly from Redfield relaxation theory.；Specifically, we construct the long-lived subspace…

The prevalence of intense loneliness is higher for social loneliness (35.8%).；Social loneliness, however, is more polarised (mean = 1.56), with many s…

After IPTW adjustment, no significant SMDs were observed between adults living alone and those not living alone.；1 presents the results of the sensiti…

Just under half were female (48.8%), and the racial and ethnic distribution was 21.5% non-Hispanic Black, 39.3% non-Hispanic White, 29.4% Mexican Amer…

Regarding life course variables, 43.7% of the older adults had illiterate parents, 64.0% experienced a lack of piped water during childhood, and 24% e…

Compared to AOMS, LOMS had higher EDSS score, higher prevalence of progressive phenotypes, and lower frequency of DMT use (all pFDR ≤ 0.016).；Both mul…

The differences for age, race, education level, marital status, current drinking, LDL-C, SII, NCDs, lipid-lowering drugs, all-cause mortality, and CVD…

The final classes were named the lower overall health burden profile (n=93, 12.42%), psychological-perceived health burden profile (n=312, 41.66%), an…

Bioinformatic analysis showed that KHSRP expression was significantly upregulated in PCa tissues compared with normal prostate tissues in the unpaired…

However, when ROS production exceeds the capacity of antioxidant defenses—whether due to increased generation or impaired scavenging—accumulated free …

During follow-ups, the proportion of participants aged ≥70 years increased markedly from 19.44% wave 1(baseline) to 49.97% at wave 3.；We also observed…

Females had lower baseline IC and a steeper decline over time than males.；Clinically, lower baseline IC was associated with reduced DFS in both sexes …

Eyes were randomly assigned (1:1) to receive intravitreal conbercept (0.5 mg) with T&E regimens using 2- or 4-week interval adjustments (Δ2w and Δ4w g…

Despite timely reperfusion and guideline-directed therapies, the recovery of left ventricular function after ST-segment elevation myocardial infarctio…

To prevent worms from seeding food-free agar with gut-retained or cuticle-bound E. coli , studies commonly employ bactericidal antibiotics (e.g., stre…

Somatic diseases in the elderly are frequently associated with comorbid depression.

Before weighting, most baseline covariates showed significant differences between the two groups (SMD > 0.1, Table ).；Compared with the metformin init…

Seventy-five participants (75%) were aged 65 years or older, indicating that the study population was predominantly situated in later adulthood.；Betwe…

Pathways associated with apoptosis, cellular senescence, DNA damage response, and EGFR tyrosine kinase inhibitor resistance were also present in the a…