时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, when ROS production exceeds the capacity of antioxidant defenses—whether due to increased generation or impaired scavenging—accumulated free radicals trigger lipid peroxidation, protein denaturation, DNA strand breakage, and ultimately programmed cell death ().
方法
Circulating irisin concentrations independently correlate with portal inflammation and hepatic redox status in NAFLD cohorts, suggesting dual potential as a biomarker and therapeutic target ().；Mechanistically, RNA sequencing confirmed that irisin enhanced antioxidant-related gene expression and activated the AMPK pathway, which in turn reduced TGF-β-induced Smad3 phosphorylation and fibronectin expression.；Commercially available enzyme-linked immunosorbent assay (ELISA) kits yield highly variable quantitative irisin measurements, ranging from ng/mL to μg/mL across different assays.
核心结论
However, when ROS production exceeds the capacity of antioxidant defenses—whether due to increased generation or impaired scavenging—accumulated free radicals trigger lipid peroxidation, protein denaturation, DNA strand breakage, and ultimately programmed cell death ().；Pharmacological inhibition of AMPK markedly attenuates irisin-facilitated Nrf2 nuclear translocation, suggesting that AMPK acts as an upstream mediator of this antioxidant cascade ().；Collectively, SIRT3 functions as a core hub linking irisin signalling to mitochondrial antioxidant defence. ‖ 结论：Future translational research should prioritize the development of metabolically stable irisin analogues with improved pharmacokinetic properties, well-powered human clinical trials to validate therapeutic safety and efficacy, and in-depth characterization of tissue-specific irisin–receptor signalling networks, to maximize therapeutic benefit and minimize potential off-target adverse effects ().
局限
Asparagine-linked glycosylation occurs at residues Asn-7 and Asn-52, contributing to molecular heterogeneity; glycosylated irisin isoforms frequently display enhanced biological activity (; ).；In addition, irisin attenuates endoplasmic reticulum stress and reduces the expression of pro-apoptotic Bax and cleaved caspase-3, limiting infarct size and preserving cardiac function ().
对本项目的价值
★☆☆☆☆ 线粒体端点既是机制解释层，也是最容易拿到体外 / 影像读数的中间层。
全文来源
PMC JATS 全文（正文 43,272 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Potential role of irisin-mediated oxidative stress defense in systemic diseases.
- 期刊与标识：Front Cell Dev Biol · PMID 42947767 · DOI 10.3389/fcell.2026.1996659
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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