时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Thus, to establish the utility of these measures for research on racial and ethnic health disparities, it is important to consider whether measures of epigenetic age are associated with health outcomes differently across racial and ethnic groups [].；The second goal of this study is to evaluate whether associations of LS7 with epigenetic age differ across five racial and ethnic groups (non-Hispanic White, non-Hispanic Black, Mexican American, other Hispanic, and another race or ethnicity).
方法
Together, the 1999–2000 and 2001–2002 cycles of NHANES comprise a nationally representative sample of 21,004 participants aged 2 months or older.；Participants were selected via a multi-stage, probability sampling design consisting of: (1) primary sampling units (PSUs) that consist primarily of single counties, (2) area segments within PSUs, (3) households within segment areas, and (4) individuals within households.；On average, 2 to 3 individuals per household were sampled, with several populations (i.e., low-income, adults aged 60 and over, non-Hispanic Black Americans, and Mexican Americans) being oversampled.；DNA samples were collected from participants aged 20 and over in the 1999–2002 cycles of NHANES to develop a nationally representative collection of genetic data for future research.
核心结论
Just under half were female (48.8%), and the racial and ethnic distribution was 21.5% non-Hispanic Black, 39.3% non-Hispanic White, 29.4% Mexican American, 6.4% other Hispanic, and 3.4% another race or ethnicity.；Among the DNAm chronological age measures, the Hannum measure demonstrated a significant inverse association with LS7 (β = –0.032, 95% CI: –0.061, –0.004), indicating that better cardiovascular health was associated with lower epigenetic age acceleration.；As shown in Table , this relationship was not attenuated after adjustment for blood cell composition (β = –0.032, 95% CI: –0.056, –0.009). ‖ 结论：When combined with previous NHANES findings showing that Black respondents had higher epigenetic age acceleration than White respondents on GrimAge, GrimAge2, and DunedinPoAm [], the results of this study suggest that epigenetic age measures trained on physiological age may help explain racial and ethnic disparities in cardiovascular outcomes.
局限
Conversely, there was not a statistically significant association between the Yang measure and LS7, suggesting that mitotic history may not be associated with lifestyle-related cardiovascular risk factors.；A key strength of this large, nationally representative analysis is its generalizability to US adults aged 50–84.；Despite these strengths, our study is subject to several limitations.
对本项目的价值
★☆☆☆☆ 生物学年龄读数是选择替代终点的主要候选，直接影响终点设计与样本量估算。最大样本量约 2,401。
全文来源
PMC JATS 全文（正文 24,523 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Life's Simple 7 score and epigenetic age acceleration: associations and effect modification by race and ethnicity.
- 期刊与标识：Clin Epigenetics · PMID 42958336 · DOI 10.1186/s13148-026-02218-6
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。