时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Bischoff‑Ferrari Received: 8 August 2026 / Accepted: 22 October 2026 © The Author(s) 2026 Abstract Chronic low-grade inflammation (“inflam- maging”) drives age-related decline, but whether anti- inflammatory medications preserve functional per- formance in older age remains unknown.；However, the risk–benefit of aspirin for primary prevention in older adults remained unclear.；However, the data available from the trial enabled annual assessment of four of the five IC domains, according to the WHO Framework (as sum- marised below).
方法
Vol.: (0123456789) GeroScience https://doi.org/10.1007/s11357-026-02624-x ORIGINAL ARTICLE Validation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial Joanne Ryan · Aung Zaw Zaw Phyo · Maud Wieczorek · Sara Espinoza · Robyn L.；A post-hoc analysis of a randomised controlled trial com- paring daily 100 mg aspirin to placebo in prolonging dementia- and disability-free survival (DFS) in commu- nity-dwelling individuals aged≥65 years.；A four-domain IC score (including cognition, locomotion, vitality and psychological well-being) was calculated annually across 18,581 participants and validated against biologi- cal and clinical measures.；Females randomized to aspirin had a small but significantly accelerated decline in IC (β:−0.006, 95% CI:−0.01,−0.001, p=0.01), whereas no effect was observed in males (p=0.
核心结论
Females had lower baseline IC and a steeper decline over time than males.；Clinically, lower baseline IC was associated with reduced DFS in both sexes (Q1 vs.；Q5: HR=4.62, 95% CI: 3.16–6.75; HR=4.32, 95% CI: 3.42–5.48). ‖ 结论：Ultimately, these findings highlight the critical need for sex-stratified analyses in geroscience trials and suggest that future interventions targeting age-related inflammation must be precision-guided to safely and effectively maintain healthy aging.
局限
Par- ticipants self-reported their sex and race (nine options, including more than one race) and ethnic- ity (Hispanic/Latino or not).；Approximately 90% of Australian participants completed questionnaires that included self-reported hearing and eyesight.；The sensory domain was calculated by averaging the z-scores of self-reported vision and hearing. i) Eyesight: At both time-points, participants rated their eyesight on a 6-point Likert scale as excellent to very poor, or completely blind.
对本项目的价值
★★★☆☆ 干预证据决定参照标准效应量——任何抗衰干预的收益至少应对标该基线。设计 randomised controlled trial；最大样本量约 18,581。
全文来源
出版商 OA PDF（正文 47,819 字符，已过 DOI 逐字 / 标题指纹归属校验）
原文题录
- 英文标题：Validation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial.
- 期刊与标识：Geroscience · PMID 42955660 · DOI 10.1007/s11357-026-02624-x
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。