时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, preference, treatment acceptability, adherence, and self-management readiness were not directly measured in the present dataset.
方法
The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative longitudinal survey of Chinese adults aged 45 years and older and their spouses, with demographic, socioeconomic, health, physical-function, lifestyle, and biomarker data.；The analytical framework first estimated a multidimensional health-burden network, then used network-informed indicators for LCA, followed by analyses of factors associated with profile membership and planned robustness analyses.；Reporting followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement; the completed checklist is provided in the .；Participants were eligible for the 2011 analysis if they were aged 60 years or older, reported physician-diagnosed arthritis or rheumatism, and reported knee pain.
核心结论
The final classes were named the lower overall health burden profile (n=93, 12.42%), psychological-perceived health burden profile (n=312, 41.66%), and multidimensional high-burden functional limitation profile (n=344, 45.93%) (, and ).；The lower overall health burden profile had comparatively low functional, psychological, perceived-health, and non-knee pain burden.；The psychological-perceived health burden profile showed relatively preserved ADL and IADL function but substantially higher depressive symptoms, poorer self-rated health, and greater non-knee pain burden than the lower-burden profile. ‖ 结论：These findings provide a rationale for multidimensional assessment that incorporates functional capacity, psychological status, perceived health, pain burden, comorbidity, sleep, and social context.
局限
This study employed a multidimensional network approach integrated with latent class analysis (LCA) to characterize the heterogeneity among older adults presenting with a symptomatic knee osteoarthritis (KOA) phenotype.；First, functional limitation, psychological symptoms, perceived health, multisite pain, metabolic factors, and comorbidity burden collectively formed an interconnected burden structure.；Second, three distinct profile classes were identified: a lower overall health burden profile; a psychological–perceived health burden profile characterized by relatively preserved activities of daily living (ADL) and instrumental ADL (IADL) function but marked elevations in depressive symptom
对本项目的价值
★☆☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。队列：CHARLS、China Health；设计 cross-sectional。
全文来源
PMC JATS 全文（正文 34,764 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Network-Informed Health-Burden Profiles Among Older Adults with Symptomatic Knee Osteoarthritis Phenotype: A Latent Class Analysis.
- 期刊与标识：Patient Prefer Adherence · PMID 42960188 · DOI 10.2147/ppa.s631987
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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