时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
The effects of ageing result in profound modifications in network architecture, including reduced segregation between functional systems, decreased efficiency of long-range communication and compensatory hyperconnectivity in prefrontaland subcortical regions., In multiple sclerosis, network integrity is further challenged by demyelination, axonal loss and neuroinflammation, resulting in altered patterns of activity and connectivity.；Similarly, longitudinal studies in healthy ageing and AOMS have shown progressive RS FC changes, reflecting a gradual shift from compensatory to inefficient network reorganization across the lifespan, supporting the notion that brain connectivity reorganization is a continuous and age-dependent process.,,, Despite this background, no studies have specifically explored RS FC profiles in LOMS, nor whether advanced age at onset shapes these patterns differently
方法
Ethical approval was obtained from the IRCCS San Raffaele ethics committee (Protocol SENESCENT-MS), and all participants provided written informed consent in accordance with the Declaration of Helsinki.；Patients were included if they met the following criteria: (i) right-handedness (Edinburgh Handedness Inventory ≥33); (ii) no major systemic, psychiatric, neurological or other comorbid conditions other than multiple sclerosis; (iii) no history of drug or alcohol abuse; (iv) no contraindications to MRI (claustrophobia, pregnancy, breastfeeding); (v) relapse- and steroid-free for at least 3 months; (vi) stable multiple sclerosis treatment for at least 6 months; (vii) no use of medications potentially affecting RS FC (benzodiazepines, antiepileptic agents, anti-fatigue treatments).
核心结论
Compared to AOMS, LOMS had higher EDSS score, higher prevalence of progressive phenotypes, and lower frequency of DMT use (all pFDR ≤ 0.016).；Both multiple sclerosis groups had higher T2-LV and lower NBV compared to their corresponding HC groups (all pFDR < 0.001).；A significant onset-category × disease-status interaction effect was observed only for T2-LV, with LOMS showing higher T2-LV compared to AOMS (pFDR = 0.028) (). shows the neuropsychological profile of AOMS and LOMS. ‖ 结论：Overall, these findings may be compatible with a less efficient pattern of functional reorganization in LOMS, potentially related to the combined effects of multiple sclerosis- and age-related factors.
局限
These findings should be interpreted as hypothesis-generating, as they did not survive correction for multiple comparisons.；The compensatory capacity observed in AOMS may be attenuated in LOMS, although the exploratory nature of these associations does not allow firm conclusions about whether RS FC increases reflect inefficient overactivation rather than effective adaptation, or whether RS FC decreases indicate network disconnection.,,,, This pattern may be compatible with the concept of network collapse, whereby age- and multiple sclerosis-related mechanisms (demyelination, synaptic inefficiency, reduced plasticity), together with structural and clinical burden, may limit functional reorgan
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。设计 cross-sectional。
全文来源
PMC JATS 全文（正文 34,841 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Advanced age at onset is associated with distinct functional brain reorganization in multiple sclerosis.
- 期刊与标识：Brain Commun · PMID 42953422 · DOI 10.1093/braincomms/fcag396
A 级证据分级：A 级（同行评议人体研究）
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