同行评议临床前研究
已发表但限于动物模型或体外实验的研究。机制描述清晰、可信度高，但结论尚不能外推至人体。
如何解读这一层级
⚠️ 临床前证据不等于人体效果。小鼠与人类在寿命跨度、代谢机制与疾病谱上差异巨大，动物实验中的寿命延长在人类语境下没有直接对应换算。
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← 返回分级说明Block-based statistical analysis of total MM-PBSA energies revealed no significant difference between SIRT1–4TQ and SIRT1–IA (p = 0.260).；In contrast,…
This ecological study examined country-level associations be-tween average household size and modelled neurological disease incidence estimates.；Count…
In AD-F mice, DHA and NR treatment also trended toward improved memory compared to AD fed chow, but the difference in latency was not significant (p =…
Quantitative analysis confirmed that argpyrimidine-positive areas were higher in the HFCS group than in the control group (mean score: 12.1% vs.；Altho…
Statistical data are presented as the mean ± SD (P < 0.01, P < 0.0001).；Statistical data are presented as the mean ± SD (*P < 0.05, P < 0.01, *P < 0.0…
A DHEA-induced murine PCOS model was generated for in vivo experiments.；Serum hormonal profiles and insulin sensitivity were assessed.；Ovarian histomo…
The first principal component accounted for 26.86% of the total expression variance, whereas the second principal component accounted for 7.71%.；SLC19…
Model Establishment For dietary intervention, the Ganoderma lucidum sporoderm-broken spore powder (GLSP) diet was prepared by uniformly mixing 4 g/kg …
结论：Thus, senescent cells are characterized by the activation of specific tumor suppressor markers, including p53/p21CIP1 and p16INK4a/Rb, which inhibi…
D-半乳糖诱导衰老大鼠接受健康供体粪菌移植后，水迷宫成绩改善，心脏、海马与结肠的组织损伤同步减轻；预先用抗生素清场反而削弱了效果。
An immunohistochemical study of the lungs of mice of different ages was performed.；The results showed that with age, there is a progressive decrease i…
During weeks 1–12, the body weight of the HFD groups was significantly higher than that of the DC group (p < 0.05 or p < 0.01), indicating a marked in…
Although its anti-tumor and anti-inflammatory effects have been extensively investigated, its potential role in transplant immunology remains unexplor…
When comparing the expression levels of individual key genes, we observed 6-fold higher expression of SEC61A1, a core translocon component; a 56-fold …
结论：Collectively, the present study demonstrates that pharmacological enhancement of endogenous 2-AG signaling through inhibition of its primary hydrol…
Protein–ligand heteroatom distances of ≤3.5 Å were observed in 8.6% of analyzed frames, while distances of ≤4.0 Å occurred in 57.0% of frames, indicat…
The 10 µM cisplatin caused approximately 70% of IHCs and 71% of OHCs to disappear, with statistically significant loss in both two types of HCs compar…
Female C57BL/6J mice aged 6 or 18 months at study onset were fed either normal food (NF) or cuprizone (0.2%) mixed into the diet for 5 weeks.；Notably,…
Here, we show that full-body Cass4 deletion in 5xFAD mice increases amyloid-β (Aβ) deposition, neuronal dystrophy, and cognitive deficits.；Since micro…
SP enriched butyrate-producing gut bacteria, including Lachnospiraceae_NK4A136_group, and increased gut and serum butyrate, consistent with enhanced m…
This study examined whether acyl-CoA synthetase long-chain family member 4 (ACSL4) contributes to BPA-associated ferro-aging-like urothelial injury.；A…
Statistical analysis is by unpaired two-tailed t test. ∗∗∗∗p < 0.0001.；B. fragilis was grown anaerobically in BHI-S (BHI with 0.5% yeast extract and 0…
We investigated whether altered AQP4 expression contributes to age-related defects in skeletal muscle regeneration and whether AQP4 may represent a ta…
For D. nanus (2022), the male extracts displayed the highest protein content (58%), followed by females (50%) and juveniles (38%).；Similarly, D. sanbo…