同行评议临床前研究
已发表但限于动物模型或体外实验的研究。机制描述清晰、可信度高，但结论尚不能外推至人体。
如何解读这一层级
⚠️ 临床前证据不等于人体效果。小鼠与人类在寿命跨度、代谢机制与疾病谱上差异巨大，动物实验中的寿命延长在人类语境下没有直接对应换算。
全部文章 · 第 21 页
← 返回分级说明Young (3-4 months) and aged (12-14 months) mice were intracerebrally (i.c.) injected with amyloid-β (Aβ1 - 42) to develop an AD-like phenotype and tre…
In an earlier issue of JGP, Hariharan et al.；(https://doi.org/10.1085/jgp.202614014) significantly add to our understanding of this pathology by showi…
Approximately 35% of the encapsulated protein was released within the first hour, followed by cumulative release values of approximately 61%, 83%, and…
Hindlimb-supported standing time was significantly reduced in aged mice (3.75 ± 0.25 s, N = 4) compared with young mice (10.8 ± 2.35 s, N = 5; p = 0.0…
Under identical conditions, the reference inhibitor roflumilast (0.1 nM) reduced activity to 43.2 ± 6.5%.；Survival rates at 168 hpf exceeded 95% in al…
However, the mechanism by which NP promotes GN progression by inducing podocyte apoptosis remains unclear.；This study aimed to determine whether NP ex…
Statistical significance levels are denoted as follows: *p < 0.05 and p < 0.01.；Biological n = 3. j Normalized VSV mRNA levels in BHK-21 cells transfe…
Moreover, support for several steps (MAC1/NOX2, HMGB1/TREM2, lipid peroxidation by-products, gut–brain signaling) comes from non-ozone or indirect mod…
衰老小鼠脑内 8-oxoGTP 累积；单独升高就足以造成突触功能障碍、tau 过度磷酸化、神经元丢失与认知下降，机制是它比 GTP 更强地激活 G 蛋白。
Building on the anticancer potential of oleuropein, a major olive tree (Olea europaea) metabolite, we evaluated a newly synthesised semi-synthetic ana…
Beyond antigen delivery, the CK5 scaffold acts as an intrinsic senomodulator associated with the downregulation of mitotic kinases Aurka/b and a conco…
线粒体呼吸链抑制导致 NADH 还原应激与 NADPH 耗竭并存；只纠正 NADH/NAD+ 无法挽救原代人成纤维细胞增殖，而扩大 NADP(H) 池可逆转增殖停滞与衰老特征。
These results identified a set of gut-serum synchronized metabolites associated with metformin-mediated improvement of lung inflammation, without esta…
In stage 1, sham-operated (SO), OVX, and OVX + MOX rats were evaluated by micro-computed tomography (micro-CT) to assess bone mass and by Alizarin Red…
Over the entire experimental period, the overall laying rate in the MSB group (76.25±2.6%) was signifi- cantly higher than that in the CON group (65.5…
At a constant chopper speed of 1400 rpm, extending the wet massing time from 3 to 7 min prompted a progressive and significant reduction in the compre…
All values are presented as mean ± SEM (n = 3). *P < 0.05, P < 0.01, *P < 0.001, **P < 0.0001. ‖ 结论**：In conclusion, this study demonstrates that comb…
For BTBR mice, the two-way ANOVA interaction for time spent in chambers was significant (F (2, 69) = 3.3, p = 0.04). ‖ 结论：For the reduction of restric…
The aim of this study was to perform a quantitative ultrastructural assessment of the mitochondrial apparatus of rat hepatocytes during aging under co…
Melatonin, a pleiotropic neuroprotective molecule with antioxidant, anti-inflammatory, and anti-apoptotic properties, has emerged as a promising candi…
Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls and young adult rats …
Cox proportional hazards regression showed no significant main effect of sex on survival (hazard ratio (HR) = 0.43, p = 0.25). ‖ 结论：Together, these fi…
心脏富集的小非编码 RNA piR-4913 在衰老心脏 I/R 后显著上调，缺血后处理可抑制它；沉默 piR-4913 缩小梗死面积、提升 ATP 并降低氧化应激，机制落在 Drp1 Thr604 的 O-GlcNAc 修饰。
(D) Analysis of the percentage of the population that was labeled showed that CLD delivered antibody into approximately 65% of the population that was…