同行评议临床前研究
已发表但限于动物模型或体外实验的研究。机制描述清晰、可信度高，但结论尚不能外推至人体。
如何解读这一层级
⚠️ 临床前证据不等于人体效果。小鼠与人类在寿命跨度、代谢机制与疾病谱上差异巨大，动物实验中的寿命延长在人类语境下没有直接对应换算。
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Celularity×Vesalius 的 8-K 把供货前提写为 FDA 依 PCAC 建议将多肽纳入 503A 可 compounding 散装物质名单；法规依据为 21 CFR 216.23。日期未公开，是本期最需持续跟踪的监管变量。
联邦公报 FR 2026-20065：咨询委员会成员与消费者组织提名材料截止 2026-11-16；FR 2026-20989：细胞、组织与基因治疗咨询委员会（CTGT AC）章程续期至 2028-10-28。
DEPH Holdings（伦敦 / 德州）任命 Lisa Loud 为 CEO（GlobeNewswire 2026-10-23，上期漏项补录）。公司主营单性别表观遗传生物年龄检测（UMMU 女性 / ENGNE 男性，居家唾液采样）。
SEC 8-K（2026-10-29）披露 Celularity 与 Vesalius Longevity Labs 签署独家生产与供应协议，在新泽西 Florham Park 建美国本土首个 Peptual® 多肽 API 终段生产平台，供货前提明确写为 FDA 依 PCAC 建议将多肽纳入 50…
However, the role of the lncRNA RMRP in endothelial cell injury and its potential molecular mechanisms remain unclear.；Mouse aortic endothelial cells …
Seven-month-old male APP/PS1 mice were randomly divided into AD-vehicle and AD-hucMSC-exosome groups, with age-matched C57BL/6 mice as wild-type contr…
In our study, the highest MDA and lowest GSH levels in hippocampal tissue were obtained in CPZ group (Group 3) and CPZ group fed a zinc-deficient diet…
A significant Treatment × Day interaction was observed in db/+ mice (p = 0.046), whereas no significant interaction was detected in db/db mice.；A sign…
Data are presented as means ± SEM with individual values shown. *P<0.001, P<0.0001.；Data are presented as means ± SEM. P<0.0001. ‖ 结论**：The present st…
结论：This study was designed to compare the predicted AD-related mechanisms of UDCA and TUDCA from the perspectives of target overlap, pathway preferenc…
In young rats, a statistically significant difference was observed among groups in terms of malondialdehyde (MDA) and sirtuin 2 (SIRT2) levels (p < 0.…
Comparisons with benchmark assays were performed.；Good detectability (CSF: 31 out of 42 assays; plasma: 38 out of 42 assays) and technical performance…
结论：We further demonstrated that this pathway mediated restraint stress–induced inhibition of NLRP6 inflammasome and autophagy, leading to impaired gob…
We delineated a nonlinear, diabetes-specific pathological trajectory characterized by early inflammatory activation, a mid-stage inflection in neurode…
A total of 47,537 high-quality cells were analyzed using the Seurat pipeline.；Differential expression, pathway enrichment (gene set enrichment analysi…
Forty-nine male SD rats were randomly divided into control group, sham-operated group, unilateral ureteral obstruction (UUO)-induced RF model group, l…
We observed an increase in body weight in female 3xTg-AD mice at 6 months (24.1%) and 12 months (28.3%) compared to B6129 mice.；This corresponded with…
For peripheral line crossings, the Two-Way Repeated Measures ANOVA demonstrated a significant Time × Group interaction [F(4, 30) = 3.093, p = 0.0303],…
在慢性鼻窦炎伴嗅觉障碍的小鼠模型中，SIRT3 缺失加剧嗅感觉神经元丢失；机制是巨噬细胞 HIF-1α 上调、糖酵解增强、线粒体膜电位下降。
Compared with the BCG group, treatment with different doses of RES (L-RES, M-RES, H-RES) combined with BCG further upregulated the expression of LC3B-…
Once the iPSC cultures reached 60–80% confluence, the iPSC maintenance medium, StemMACS XF (Miltenyi Biotec, Auburn, CA, USA), was replaced with Neuro…