代谢干预与营养
NAD+ 前体、mTOR 抑制剂、GLP-1 受体激动剂、热量限制与限时进食。代谢是衰老最核心的驱动因素之一。
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Recent global-scale analyses further demonstrate that their occurrence is both widespread and highly heterogeneous. ) compiled 6,4…
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Diabetic neuropathy (DN) is one of the most common and debilitating complications of diabetes; approximately half of all people wi…
While systemic drivers reduce intrahepatic lipid partly through weight loss and improved peripheral metabolism, their direct long‑…
MFPM1 treatment reversed these changes, as evidenced by a reduced NADP⁺/NADPH ratio, restored GSH/GSSG ratio, increased T-AOC, and…
Beyond its traditional role as a metabolic byproduct, lactate is now recognized as a signaling molecule that links metabolism to e…
该综述把线粒体移植的定位从单纯的“能量替代”推进到代谢与免疫重编程，并系统梳理了线粒体的组织来源、分离与保存、体内递送路径以及质量控制重塑等全流程环节。
( ) demonstrated in collagen-induced arthritis (CIA) mice that mtSTAT3 overexpression significantly reduced arthritis scores, alle…
We then cultured BEAS-2B cells and HUVECs separately on petri dishes, or co-cultured BEAS-2B cells and HUVECs using Transwell.；ELI…
In females, farnesyl pyrophosphate synthase increased (TRINITY_DN896_c0_g1, log 2 FC = +1.436, FDR = 7.05 × 10 −15 ), consistent w…
No analyses of the primary or secondary outcomes have been performed. ‖ 结论：These methodological limitations should be considered w…
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Consistent with this finding, we observed that HF diet significantly impaired insulin sensitivity and glucose regulation, whereas …
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Successful establishment of the PSC model was evidenced by a systemic increase in liver injury markers (AST, ALT, ALP, and T-bil),…
The read length N50 of muscle samples (12.97 ± 2.48 Kb) was significantly longer than that of hair samples (3.49 ± 0.83 Kb, P-valu…
Antibiotic information was largely missing, and systemic or inhaled steroid exposure was recorded only for wheezers.；Wheezers had …
In NAFLD-related models, LBP activated the PGC-1α/NRF1/TFAM pathway to promote mitochondrial biogenesis, accompanied by increased …
Nature 旗下 Briefing Chat 播客节目讨论宠物长寿议题：伴侣动物的衰老研究正成为长寿科学的一个独特试验场——它们与人类共享环境，但寿命短得多。
The course of NAFLD is variable, with NAFLD potentially progressing to cirrhosis and hepatocellular carcinoma, making it a major c…
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GeroScience 研究：雄性 C57BL/6J 小鼠（每组 60 只）随机分入 T≈22h、T=24h、T≈26h 三种光周期，叠加季节性光暗比例变化；结果显示健康期指标被改变，但总生存未变。