时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Renal biopsy remains the reference standard for histological assessment of fibrosis; however, its invasive nature limits repeated assessment.；A major challenge in renal mpMRI research is the lack of standardized protocols for image acquisition, postprocessing, and analysis.；The primary objective of the multiparametric renal magnetic resonance imaging (MPRENAL) study is to evaluate the association between time-dependent changes in the corticomedullary T1 difference and progression of histologically determined fibrosis in KTRs, with further MRI measures examined in a fixed order specified in advance of analysis.
方法
This is a multicenter, prospective, longitudinal observational cohort study including LKDs, KTRs, and HCs.；Participants will undergo repeated assessments over a 24-month follow-up period.；As illustrated in , the study follows a longitudinal trajectory over 24 months for all 3 cohorts.；Following the baseline assessment, participants undergo follow-up visits at 3, 12, and 24 months.
核心结论
No analyses of the primary or secondary outcomes have been performed. ‖ 结论：These methodological limitations should be considered when interpreting associations among imaging biomarkers, histological findings, and functional outcomes in the present study.
局限
A key limitation of this study is the spatial mismatch between the focal needle biopsy samples and the cortical and medullary ROIs assessed by mpMRI.；An additional limitation relates to temporal alignment of baseline assessments in KTRs, as described in the Methods.；Associations involving baseline should therefore be interpreted with caution.
对本项目的价值
★☆☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。
全文来源
PMC JATS 全文（正文 55,426 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Multiparametric Magnetic Resonance Imaging in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls and Correlations With Markers of Renal Function, Fibrosis, and Aging (MPRENAL): Protocol for a Longitudinal Observational Study.
- 期刊与标识：JMIR Res Protoc · PMID 42954158 · DOI 10.2196/97152
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