时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
They do not, however, directly measure lower-airway communities.；To address this gap, we characterized stool and nasal bacterial communities in children aged 1–4 years with recurrent wheeze (n=17) and healthy controls (n=8) in a cross-sectional exploratory pilot study.
方法
The ALLIANCE cohort of the German Center for Lung Research (DZL) is a prospective multicenter asthma cohort recruiting in five pediatric specialist centers (Hannover, Luebeck, Munich, Marburg and Cologne) and two adult specialist centers (LungenClinic Grosshansdorf and Research Centre Borstel), registered at ClinicalTrials.gov (pediatric arm , adult arm ) and ethically approved across all study centers.；Parents of study participants aged < 18 years and study participants aged ≥ 18 years gave written informed consent.；Two children were excluded because their nasal swabs yielded no bacterial sequencing reads; their corresponding stool samples were also excluded to maintain paired analyses, resulting in 17 wheezers.；Details regarding study design, parameter definitions, inclusion criteria, and methods are provided in the and have been published previously [].
核心结论
Antibiotic information was largely missing, and systemic or inhaled steroid exposure was recorded only for wheezers.；Wheezers had higher thrombocyte and blood basophil counts (Fisher’s exact p=0.045 and p=0.036, respectively); no statistically supported differences were observed for the other measured hematological or immunological parameters.；Group-specific core ASV decreased rapidly with increasing prevalence thresholds in both compartments, indicating limited overlap between individuals (Fig. a; Supplementary Table ). ‖ 结论：These findings do not establish Moraxella-driven clustering or causality.
局限
In this cross-sectional exploratory pilot study, we analysed paired nasal and stool bacterial communities from preschool children with recurrent wheeze and HC.；The main results therefore concern heterogeneity of nasal profiles rather than a consistent group-wide microbial signature.；This observation does not establish Moraxella as a driver and may reflect prior viral infection, treatment exposure, host immunity, or another unmeasured factor.
对本项目的价值
★☆☆☆☆ 菌群是可远程部署、成本最低的干预变量，但因果性与个体化响应仍是主要瓶颈。设计 cross-sectional。
全文来源
PMC JATS 全文（正文 24,551 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Exploratory analysis of nasal and gut microbial community structure in preschool children with recurrent wheeze.
- 期刊与标识：Microb Ecol · PMID 42955378 · DOI 10.1007/s00248-026-02867-3
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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