时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
Unlike previous reviews mainly focusing on the general antioxidant or anti-inflammatory activities, this review emphasizes the links among NP structural features, mitochondrial homeostasis, and disease-context-specific therapeutic…；We also discuss current challenges and future directions for developing NPs as mitochondria-regulating therapeutic candidates. 2
方法
（原文未给出可直接抽取的对应表述）
核心结论
In NAFLD-related models, LBP activated the PGC-1α/NRF1/TFAM pathway to promote mitochondrial biogenesis, accompanied by increased ATP production, reduced oxidative stress, and decreased hepatic lipid accumulation ( ).；These effects were accompanied by ROS accumulation, altered oxygen consumption, reduced UCP2 protein expression, and decreased lactate production ( ).；Likewise, Ganoderma lucidum polysaccharides (GLP) decreased p-Drp1 and Fis1 expression while increasing Mfn1, Mfn2, and OPA1 levels, thereby attenuating pathological mitochondrial fragmentation in mice ( ).；In cardiomyocyte injury associated with metabolic stress, aging, or other stressors, NPs appear to attenuate mitochondria-dependent apoptosis and calcium-related mitochondrial dysfunction.
局限
Fifth, clinical translation requires stronger human evidence. polysaccharide-K and lentinan have been used regionally as adjunctive cancer therapies, while fucoidan has undergone preliminary clinical evaluation ( ; ; ).；Despite advances in targeted therapy and immunotherapy, treatment failure remains common because of tumor heterogeneity, recurrence, and drug resistance ( ).
对本项目的价值
临床前机制证据，需评估物种外推与剂量可行性：线粒体是衰老干预的共同下游效应器，可用于跨器官效应的统一读数。 ｜ 价值分 1.7/5（★★☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 49,547 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Natural polysaccharides as modulators of mitochondrial homeostasis: structural determinants, pharmacological mechanisms, and translational challenges.
- 期刊与标识：Frontiers in pharmacology · PMID 42953059 · DOI 10.3389/fphar.2026.1948381
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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