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共 2198 篇,本页第 961–990 篇
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Almost all students worked with older adults in their profession or job (98.6%) or visited a nursing home or a geriatric clinic (88.4%).;Interrater ag…
Of these, 147 used a phone that was incompatible with the Huawei Health app (eg, iOS devices or unsupported Android versions), 64 did not proceed beca…
Structural equation modeling showed that greater xerostomia symptom severity was not significantly associated with nutritional vulnerability ( B = 0.1…
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Recent studies have suggested a link between Yes-associated protein(YAP) and VC, but the underlying mechanisms remain poorly defined.;In a rat CKD mod…
Pluri 取得 ZEO 董事会 7 席中 4 席的提名权(需持股 ≥25% 且未发生控制权变更),交割时须任命 Pluri CEO Yaky Yanay 入董事会;现有 CMO 等约 4% 股份置换为 Series D 优先股,非离任。
ZEO 向 Pluri 发行 41% 已发行股本与 50 股 Series D 优先股,换取 Pluri 现有及未来再生医学产品组合在美国的独家生产与商业化许可,版税随 Pluri 持股比例下降阶梯上调。
To evaluate, using microtensile bond strength (μTBS) testing and in situ zymography, the effects of an experimental zirconium oxynitrate-based etchant…
Efferocytosis is a specialized phagocytic program for apoptotic cells that is often immunologically silent or tolerogenic and engages phosphatidylseri…
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In terms of education, 22.50% had primary school education or below, 34.48% had middle school education, 34.80% had a high school degree, and 8.22% he…
Co-transplantation of hucMSC-EVs with 250 islet equivalents significantly improved glycaemic control (p<0.01) and glucose tolerance (p<0.01) in diabet…
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Introduction Organisms develop in chemically complex environments and have evolved to respond not only to their endogenous metabo- lites but also to e…
Consistently, immunofluorescence staining showed that the SESN2 signal was significantly increased in the SESN2-OE group and markedly decreased in the…
Consistent with our previous sequencing data identifying miR-543 as the most significantly dysregulated miRNA in female FGR placentas (), qRT-PCR vali…
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While some trajectories showed predominantly monotonic changes across the lifespan, including monotonic increases (e.g., F30:M70) or decreases (e.g., …
港股励晶太平洋(00575.HK)公告:旗下 Deep Longevity 的美国消费者远程医疗平台 Accrua Health 延至 2026 年第四季度推出,分三阶段,首发主打减重与长寿抗衰肽类药物,核心为 AI 生成的 BloodAge 报告。
Eos SENOLYTIX 公布 MitoXcel 先导肽 PTC-2105 在老年大鼠中的中期结果:Week 16 rotarod 基本维持基线而溶媒组下降约 76%(p=0.012,n=3/4),握力与脂肪量数据见正文;IND-enabling 推进中。
HHS 发布《关于使用特定多肽散装物质进行 503A 配制的执法裁量政策》草案(FR 2026-22192 / 91 FR 68526),对 BPC-157、TB-500、MOTS-c、Epitalon、Semax、KPV 六种多肽暂不执法,条件严苛且不覆盖 503B 与复方。
本研究用人源体系直接回答"骨髓微环境(而非 HSC 本身内在变化)在衰老中贡献几何":衰老的人骨髓间充质基质细胞(hBMSC)作为重要的微环境调控者,推动年轻造血干细胞(hHSC)向髓系偏斜分化;并且 hBMSC 在再生诱导的应激中对 hH
人类细胞外基质相关基因 FREM3 表现出强烈年龄依赖性、富集于年龄敏感的长程投射兴奋性神经元、并与神经退行性疾病相关;作者构建兴奋性神经元特异的 Frem3 条件敲除小鼠(Frem3-cKO)并在人群中计算 FREM3 的遗传调控表达(F
在 PNC 队列 755 名 8–22 岁参与者中比较 PCA、ICA、NMF、OPNMF 与 k-means 五种体素级结构协方差表示,PCA 与 OPNMF 的成分权重与年龄关联最强,NMF/OPNMF/k-means 与纤维束投射空间
ADNI 615 名参与者中 α-synuclein SAA 阳性 117 人(19.0%);横断面 meta-temporal tau 的 αSyn×淀粉样交互 beta 0.258(95% CI 0.023–0.493,p = 0.03
KOLF2.1J iPSC 来源人神经元中,rs28834970 的 C 风险等位促进 C/EBPβ 结合,CC 纯合使总 PYK2 降低超过 80% 且磷酸化 PYK2 占比升高;转录组见 724 个下调与 113 个上调基因集。
在 NHANES 1999–2000 与 2001–2002 周期的分析中,蛋白质摄入以 g/kg/天表示,生物学年龄(BA)用 端粒长度(TL)、AnthropoAge、PhenoAge 与 Klemera-Doubal 法(KDM)估计