时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Despite this, little is known about how virus receptor expression in the human brain varies by sex and age.；This gap is significant given evidence that severe infections can leave behind structural and transcriptomic signatures resembling brain aging [,].；We also performed a targeted prenatal analysis to determine whether sex differences in virus receptor expression are already established during corticogenesis.
方法
The Hamilton Integrated Research Ethics Board reviewed and approved the use of the dataset in this study.；We analyzed postnatal human brain transcriptomic data from Kang et al.；The study focused on postnatal development using data from 15 brain areas with lifespan sampling for both sexes: 11 cortical areas (OFC, DFC, VFC, MFC, M1C, S1C, IPC, A1C, STC, ITC, V1C) and 4 subcortical areas (HIP, AMY, MD, CBC)(total tissue samples: n = 700; 306 females, 394 males) ().；The postnatal dataset comprised 33 postnatal donors (aged 4 months to 82 years; 14 female).
核心结论
While some trajectories showed predominantly monotonic changes across the lifespan, including monotonic increases (e.g., F30:M70) or decreases (e.g., F36:M64(1)), the majority were characterized by non-linear, often undulating trajectories, with peaks and troughs occurring at different developmental stages (e.g., F100:M0, F13:M87; ).；Clusters differed widely in their female-to-male composition (), with several clusters exclusively or strongly biased toward females (e.g., F100:M0, F97:M3) or toward males (e.g., F13:M87, F4:M96), and others containing trajectories from females and males in roughly equal proportions (e.g., F47:M53).；Inspection of clusters containing both sexes indicated that most trajectories differed across gene–brain area combinations in females and males (), suggesting that females and males preferentially allocate different gene–area combinations to shared trajectory shapes. ‖ 结论：Our findings advance a framework in which developmentally regulated, sex-biased receptor programs define the molecular terrain upon which neurotropic viral exposure unfolds.
局限
Its successful performance demonstrates that these trajectories capture reproducible biological organization that generalizes from population-level developmental programs to individual brains, rather than simply describing average group trends.；Future studies characterizing developmental changes in this system in females and males will be essential for understanding how vascular and parenchymal mechanisms converge to shape brain vulnerability.；Several limitations should be considered when interpreting these findings.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
全文来源
PMC JATS 全文（正文 49,588 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Sex- and age-specific development of ssRNA virus receptor expression in the human brain.
- 期刊与标识：PLoS One · PMID 42956020 · DOI 10.1371/journal.pone.0360526
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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