同行评议人体研究

已在同行评议期刊发表的人体研究,包括随机对照试验、队列分析与临床试验中期数据。这是本站证据等级中可信度最高的一类。

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需注意:即使是 A 级人体研究,样本量与随访时长仍可能不足以支撑强结论。涉及企业发布的中期数据时,本站会在正文中另行标注。

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研究进展 A 2026-11-01 代谢与营养

Regarding mitochondrial function, MMP was reduced and ROS accumulation was increased, and ATP content was significantly decreased in the COPD group.;W…

研究进展 A 2026-11-01 细胞衰老

These differences in sample type distribution between UR and baseline cohort was statistically significant (p = 0.0002).;In the overall, KR, and UR co…

研究进展 A 2026-11-01 细胞衰老

Of these cases, 387 were diagnosed before age 55 years (204 women, 183 men) and 6233 were diagnosed at age 55 years or older (2702 women and 3531 men)…

研究进展 A 2026-11-01 生命历程

Population aging and the rapid diffusion of generative artificial intelligence are two defining transformations of the twenty-first century, yet they …

研究进展 A 2026-11-01 免疫与炎症

The discovery cohort consisted of 456 individuals including 410 individuals with relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS), …

研究进展 A 2026-11-01 免疫与炎症

Survival analysis of different groups of patients under CONUT score and GNRI score For CONUT scores, higher scores were linked to increased all-cause …

研究进展 A 2026-11-01 器官衰老

Abdominal aortic aneurysm (AAA) is a degenerative condition involving several processes including inflammation, matrix remodeling, disruptions of vasc…

流行病学 A 2026-11-01 器官衰老

Institutionalized participants were significantly older than community-dwelling participants (81.10 ± 7.82 vs. 72.44 ± 6.17 years, p < 0.001).;Communi…

流行病学 A 2026-11-01 器官衰老

BMI and BMI category were not significantly associated with any of the three scale scores.;PSQI, FRAIL, and SWLS total scores also differed significan…

流行病学 A 2026-11-01 器官衰老

Frailty is a complex syndrome characterized by diminished physiological reserves, resulting in increased vulnerability among older adults. Scalable to…

研究进展 A 2026-11-01 器官衰老

Both scores were independently associated with severe morbidity (mFI-5 OR 1.41, 95% CI 1.06-1.86; TG18 Grade III vs I OR 2.66, 1.25-5.62), and adding …

研究进展 A 2026-11-01 生命历程

Absolute load, relative load, and the number of repetitions differed significantly between the IND and NON‐IND groups (p < 0.001).;All velocity‐relate…

研究进展 A 2026-11-01 细胞衰老

Univariate Cox regression analysis was first conducted to identify glycolysis-related genes significantly associated with overall survival.;Based on t…

研究进展 A 2026-11-01 神经退行

There were no significant differences between the older and younger age groups in years of education (older = 16.25 ± 2.41; younger = 16.70 ± 1.87; p …

研究进展 A 2026-11-01 代谢与营养

Elderly femoral shaft fractures present unique challenges due to physiologic vulnerability and medical comorbidity, yet the perioperative outcomes ass…

流行病学 A 2026-11-01 神经退行

Fear of falling (FoF) avoidance behavior (FFAB) is common in Parkinson disease (PD) and contributes to reduced activity, deconditioning, and functiona…

研究进展 A 2026-11-01 器官衰老

Prognostication remains challenging in this population because frailty and comorbidity burden greatly influence recovery trajectories.;Tailored progno…

研究进展 A 2026-11-01 器官衰老

Regarding performance on the applied tests, it was found that the average score on the ABC Scale increased from 47.9% to 50.1% at the end of the inter…

研究进展 A 2026-11-01 神经退行

Novel object recognition (NOR) and location (NOL) tasks capitalize on rodents’ innate novelty preference and have revealed significant corticolimbic c…

研究进展 A 2026-11-01 方法与工具

Conversely, the model identified factors associated with reduced predicted risk, including hypercholesterolemia, allergic rhinitis, and chronic period…

临床试验 A 2026-11-01 生命历程

Of note, there were no differences in whole-brain WMH volume at baseline [t(58.6) = 0.43, estimated mean difference = 0.04, 95% CI = −0.14 to 0.22, P …

研究进展 A 2026-11-01 免疫与炎症

There was no significant difference in the thymic score distribution between the MG and control groups.;The data showed that MG patients had significa…

研究进展 A 2026-11-01 生命历程

Rural and Remote Health 2026; 26: 11434. https://doi.org/10.22605/RRH11434 r Rural and Remote Health www.rrh.org.au James Cook University ISSN 1445-63…

研究进展 A 2026-11-01 生命历程

The iRGD peptide mediates tumor-selective extravasation and penetration by binding to integrin αvβ3 or αvβ5, which are often overexpressed on tumor va…