时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
However, the expression pattern and functional significance of ABCB1 in COPD, particularly in relation to mitochondrial dysfunction, have not been fully elucidated.；This study was designed to evaluate the potential protective properties of Rg1 in experimental models of COPD, including both animal and cell‐based systems, and to elucidate whether these effects are mediated through ABCB1‐dependent…
方法
All statistical analyses were performed using GraphPad Prism 9.0 software.；Primer sequences are listed below. 2.14 Transmission Electron Microscopy (TEM) Lung tissue samples were pretreated and fixed with 2.5% glutaraldehyde (16220, Electron Microscopy Sciences, PA, USA) at 4°C overnight.；Cells were finally resuspended in an appropriate volume of buffer for analysis by flow cytometry. 2.10 Detection of Mitochondrial ROS by MitoSOX Cells were seeded into six‐well plates according to experimental grouping.
核心结论
Regarding mitochondrial function, MMP was reduced and ROS accumulation was increased, and ATP content was significantly decreased in the COPD group.；We found that Rg1 markedly improved lung architecture, reduced collagen deposition, attenuated inflammatory cytokine production, and restored pulmonary function in CS‐induced COPD rats.；Furthermore, we showed that Rg1 restored MMP, reduced mitochondrial ROS accumulation, rescued intracellular ATP depletion, and inhibited apoptosis in CSE‐treated HBE cells.；In terms of pulmonary function, Ri was significantly increased, whereas Cdyn and FEV0.3/FVC were significantly decreased in the Model group.；In summary, our findings indicate that Rg1 mitigates COPD‐associated lung injury in a manner associated with ABCB1 upregulation and restoration of mitochondrial function, as well as inhibition of AGEs–RAGE and EGR1–JNK signaling.
局限
Future studies employing ABCB1‐specific pharmacological inhibitors or conditional knockout models are warranted to establish the causal role of ABCB1 in mediating the protective effects of Rg1.；Second, the CS‐induced rat model and CSE‐treated HBE cells cannot fully recapitulate the complexity and heterogeneity of human COPD.
对本项目的价值
临床前机制证据，需评估物种外推与剂量可行性：线粒体是衰老干预的共同下游效应器，可用于跨器官效应的统一读数。 ｜ 价值分 1.7/5（★★☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 32,337 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Ginsenoside Rg1 Alleviates Chronic Obstructive Pulmonary Disease Partially Through Regulating ABCB1-Mediated Mitochondrial Dysfunction.
- 期刊与标识：Journal of biochemical and molecular toxicology · PMID 42952251 · DOI 10.1002/jbt.71160
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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