时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
Sleep quality and life satisfaction are important dimensions for understanding frailty in older patients with multimorbidity.；Sleep disturbances are common in older adults and are intertwined with chronic diseases, pain, psychological symptoms, medication use, and functional
方法
Because the median number of chronic diseases in the clinical data was 5, participants were classified into a lower-burden group (< 5 chronic diseases) and a higher-burden group (≥ 5 chronic diseases).；method treats variables as nodes and statistical associations adjusted for other nodes as edges, allowing the description of relative node connectivity and cross-domain association patterns [ – ].；To descriptively explore network patterns by chronic disease burden, participants were classified into a lower-burden group (< 5 chronic diseases) and a higher-burden group (≥ 5 chronic diseases).
核心结论
BMI and BMI category were not significantly associated with any of the three scale scores.；PSQI, FRAIL, and SWLS total scores also differed significantly by smoking status, drinking status, education level, and primary source of financial support (all P < 0.001).；Taken together, bridge strength and bridge expected influence suggest that life satisfaction nodes were characterized mainly by stronger absolute cross-community connections, whereas sleep quality nodes were relatively more prominent in signed cross-community…；Stability analysis of network centrality and bridge centrality As the proportion of dropped cases increased, the correlations between the re-estimated and original indices for strength, expected influence, bridge strength, and bridge expected influence…
局限
Because this study used a cross-sectional design, the network results reflect statistical associations among nodes and cannot establish causal directions among sleep problems, frailty, and life satisfaction.；Methods Study design and participants This cross-sectional study enrolled older patients treated in the Department of Geriatrics, Jingzhou First People’s Hospital, from February to April 2025.
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：功能结局（衰弱 / 肌少症）是临床转化最可及的终点，适合作为一期终点候选。 ｜ 价值分 1.8/5（★★☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 44,451 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Network analysis of frailty, sleep quality, and life satisfaction in older patients: a cross-sectional study stratified by chronic disease burden.
- 期刊与标识：BMC geriatrics · PMID 42958059 · DOI 10.1186/s12877-026-07958-x
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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