时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
The objectives of this study were to (1) examine the impact of a 12-month resistance training intervention on WMH progression in individuals living with SVCI, (2) determine the influence of biological sex on intervention effects and (3) evaluate whether changes in exercise-secreted growth factors are associated with WMH changes.
方法
We received ethical approval from The University of British Columbia Clinical Research Ethics Board (H15-00972) and the Vancouver Coastal Health Research Institute (V15-00972).；In accordance with the Declaration of Helsinki, all participants provided written informed consent before study enrolment.；This study followed the CONSORT reporting guidelines and was registered on 1 February 2016, with ().；We recruited participants through the Clinic for Alzheimer's Disease and Related Disorders at The University of British Columbia Hospital, through affiliated clinics at Vancouver General Hospital, and via community advertisements.
核心结论
Of note, there were no differences in whole-brain WMH volume at baseline [t(58.6) = 0.43, estimated mean difference = 0.04, 95% CI = −0.14 to 0.22, P = 0.667] between male [mean (SD) = 0.83 (0.41), log-transformed cm3] and female [0.87 (0.38)] participants or in any of the regional WMH volumes (all P > 0.136). shows the spatial distribution of WMH at baseline.；However, we found significant region-specific effects of the intervention wherein RT led to greater reduction in WMH volume in the temporal lobe and splenium of the corpus callosum versus BAT (see and ).；We found a significant group-by-sex interaction [F(1,65) = 5.82, P = 0.019], indicating that the effect of the intervention on WMH volume differed by sex [estimated mean difference-of-differences (95% CI) = −0.093 (−0.170 to −0.016), P = 0.019]. ‖ 结论：Our findings suggest that this type of training may be an important non-pharmacological approach to mitigating disease progression in adults aged 55 and over living with SVCI, especially among female individuals.
局限
We highlight that sex-specific effects should be interpreted with caution as our multiple-imputation analysis did not corroborate these findings, and the study was not powered to detect sex effects, particularly given the imbalance in sex distribution wherein twice as many females were included across groups.；Our sample comprised highly educated and mostly female participants with low WMH lesion load, which may reduce the generalizability of our findings.；We did not collect data on racial and ethnic identities of participants or other measures of socioeconomic status such as income; these data would have provided additional context to the generalizability of our findings.
对本项目的价值
★☆☆☆☆ 干预证据决定参照标准效应量——任何抗衰干预的收益至少应对标该基线。
全文来源
PMC JATS 全文（正文 30,677 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Exercise and white matter hyperintensities: a randomized clinical trial.
- 期刊与标识：Brain Commun · PMID 42948654 · DOI 10.1093/braincomms/fcag381
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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