时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Building on this work, the present study used whole-brain voxel-based morphometry (VBM) to examine whether gray matter associations extended beyond predefined regions in an expanded, partially overlapping sample of cognitively unimpaired older adults.；Following the approach used in the prior study , participants were stratified into relatively younger (<70 years) and older (≥70 years) groups to determine whether the previously reported age-stratified pattern remained evident in the expanded sample using whole-brain VBM.；We hypothesized that greater perceived financial exploitation vulnerability would be associated with lower gray matter volume in the older group, particularly in medial temporal and default mode network regions vulnerable to aging and preclinical AD.
方法
Participants were recruited from community outreach events, local senior centers, and the Alzheimer's Prevention Registry in the greater Los Angeles area.；Inclusion criteria for the FCDNA study required participants to be at least 50 years of age and fluent in English.；Eligible participants completed an in-laboratory visit consisting of self-report behavioral questionnaires, comprehensive neuropsychological assessment, and magnetic resonance imaging (MRI).；For the present study, we selected 128 participants (aged 51 to 87 years, 76% female) from the broader FCDNA study who obtained a score of 26 or higher on the Mini-Mental Status Examination , consistent with prior work using this threshold to define cognitively unimpaired older adults , .
核心结论
There were no significant differences between the older and younger age groups in years of education (older = 16.25 ± 2.41; younger = 16.70 ± 1.87; p = 0.237) or sex distribution (70% vs. 81% female; p = 0.260; see for full demographic characteristics).；Racial and ethnic composition was similar across groups, with the overall sample identifying as 68% White, 20% Asian, 5.5% Black or African American, 4.7% Multiracial, 1.6% Other, and 0.8% Unknown.；Age groups differed modestly in global cognition as measured by the MMSE, with lower scores in the older group (28.36 ± 1.23) relative to the younger group (28.88 ± 1.11; p = 0.013). ‖ 结论：The findings highlight the potential value of considering financial vulnerability alongside cognitive, psychosocial, and functional measures when examining individual differences across later adulthood.
局限
Because these analyses were based on clusters selected from the primary VBM analyses, they were not independent confirmatory tests and should be interpreted as exploratory characterization of the observed associations.；Together, the findings indicate cross-sectional associations between perceived financial exploitation vulnerability and regional gray matter volume that may vary across later adulthood.；Preliminary studies in Greek samples have also associated financial capacity with right amygdala and left angular gyrus volumes and financial literacy with left amygdala volume in samples including healthy older adults and individuals with amnestic mild cognitive impairment , .
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。设计 cross-sectional。
全文来源
PMC JATS 全文（正文 29,880 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Age-dependent gray matter correlates of perceived financial exploitation vulnerability in cognitively unimpaired older adults.
- 期刊与标识：Aging Brain · PMID 42960243 · DOI 10.1016/j.nbas.2026.100173
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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