时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
PRISMA flow diagram. 2 Serene Lee et al. https://doi.org/10.1017/S1092852926101291 Downloaded from https://www.cambridge.org/core.；IP address: 62.234.205.54, on 31 Oct 2026 at 17:41:17, subject to the Cambridge Core terms of use, available at https://www.cambridge.org/core/terms. gender-based AD outcomes, and provide an update on estrogen- mediated pathways.
方法
（原文未给出可直接抽取的对应表述）
核心结论
Discussion Herein, through a narrative review, we identified evidence from the current literature supporting structural and molecular differences in GLP-1, insulin, and metabolic signalling that may be responsible for the increased susceptibility of women to…
局限
However, mechanistic uncertainty, study heterogene- ity, and limited sex-specific evidence warrant caution when extend- ing these findings to AD prevention.；Further heterogeneity across study designs, animal and human populations, GLP-1RA agents, routes of administration, age groups, and outcome mea- sures limits direct comparability across findings.
对本项目的价值
综述级证据，用于快速对齐领域共识与空白：神经退行是长寿干预最难攻的终点，本文提供机制或生物标志物层面的抓手。 ｜ 价值分 1.2/5（★☆☆☆☆）
全文来源
出版商 OA PDF（正文 24,372 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Sex differences in glucagon-like peptide-1 signalling and the implications for Alzheimer's disease: A narrative review.
- 期刊与标识：CNS spectrums · PMID 42952261 · DOI 10.1017/s1092852926101291
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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