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基础研究 B 2026-11-01 方法与工具

Low socioeconomic position (SEP) is a significant determinant of poor health. The embodiment of SEP into biology functioning and then on health status…

基础研究 B 2026-11-01 方法与工具

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基础研究 B 2026-11-01 生命历程

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基础研究 B 2026-11-01 生命历程

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribut…

基础研究 B 2026-11-01 器官衰老

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基础研究 B 2026-11-01 神经退行

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基础研究 B 2026-11-01 生命历程

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基础研究 B 2026-11-01 代谢与营养

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研究进展 A 2026-11-01 器官衰老

Nature Aging Statinspromoteboneanabolism inestrogendeficiencybyinducing osteogenicdifferentiationofskeletal stem/progenitorcells Min Yang1,2,3,12 , Ji…

基础研究 B 2026-11-01 细胞衰老

CCK‐8 results showed that Stemonine had no significant effect on cell viability after 48 h of treatment at concentrations ranging from 0 to 800 μM (Fi…

基础研究 B 2026-11-01 代谢与营养

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基础研究 B 2026-11-01 器官衰老

From 1990 to 2023, the total burden of stroke in India has increased.;Stroke deaths also increased during this time, rising from 416,863 to 1.03 milli…

基础研究 B 2026-11-01 器官衰老

Tear-trough deformities and infraorbital hollows are common signs of aging in the periocular region and may contribute to a depressed, fatigued facial…

流行病学 A 2026-11-01 神经退行

The two groups were well-matched for age (p = 0.105), sex (p = 0.231), years of education (p = 0.210), and body mass index (p = 0.350).;In contrast, p…

基础研究 B 2026-11-01 神经退行

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基础研究 B 2026-11-01 器官衰老

To estimate the incidence and clinical characteristics of submacular hemorrhage (SMH) requiring procedural intervention during anti-VEGF therapy for n…

研究进展 A 2026-11-01 生命历程

Between 2012 and 2024, 46,546 completed suicides were registered in Kazakhstan, averaging 3,580 cases per year (95% CI: 3,390-3,760).;Based on an anal…

流行病学 A 2026-11-01 代谢与营养

Poorer family relationships, absence of hobbies or interests, less frequent outdoor activity, and the presence of retinopathy or another eye disease w…

综述解读 C 2026-11-01 神经退行

Gait dysfunction is a preclinical marker of Alzheimer disease (AD) and related dementias (ADRD), often emerging years before clinical diagnosis. While…

基础研究 B 2026-11-01 生命历程

The purpose of this in vitro study was to assess the impact of sintering protocols (conventional versus super-speed) and thermomechanical aging on the…

基础研究 B 2026-11-01 生命历程

The overall model was statistically significant and explained a very large proportion of the variance in SBS (R2 = 0.964, adjusted R2 = 0.961).;The 3-…

综述解读 C 2026-11-01 神经退行

Forty reports were excluded because they were reviews or commentaries, lacked a direct sustainability outcome, were not orthodontic in scope, or used …

综述解读 C 2026-11-01 生命历程

Cancer and its treatments can have long-term adverse effects that may accelerate aging and worsen symptom burden. The cognitive and behavioral strateg…

研究进展 A 2026-11-01 神经退行

Synapses act as core computational units that support higher cognitive functions in the brain.;Early defects in synaptic signaling and impairments in …

研究进展 A 2026-11-01 生命历程

Transcatheter aortic valve implantation (TAVI) is increasingly performed in older adults with severe aortic stenosis, but there is limited evidence on…

基础研究 B 2026-11-01 代谢与营养

Interestingly, positive endosomes are not present in every cell or every animal and can vary from just a few to hundreds.;We found that regulates loca…

基础研究 B 2026-11-01 神经退行

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基础研究 B 2026-11-01 生命历程

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预印本 C 2026-11-01 神经退行

值得记进版图的原因是「二级蛋白病」这个提法:病灶里不只有主角。如果这条在哺乳动物里复现,那么「单一靶点清除」的效果上限就有了另一个解释。

基础研究 B 2026-11-01 神经退行

Using porcine hemagglutinating encephalomyelitis virus (PHEV) as a model, we identify TRAPγ in a genome-wide CRISPR-Cas9 screen as essential for produ…