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Low socioeconomic position (SEP) is a significant determinant of poor health. The embodiment of SEP into biology functioning and then on health status…
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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribut…
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Nature Aging Statinspromoteboneanabolism inestrogendeficiencybyinducing osteogenicdifferentiationofskeletal stem/progenitorcells Min Yang1,2,3,12 , Ji…
CCK‐8 results showed that Stemonine had no significant effect on cell viability after 48 h of treatment at concentrations ranging from 0 to 800 μM (Fi…
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From 1990 to 2023, the total burden of stroke in India has increased.;Stroke deaths also increased during this time, rising from 416,863 to 1.03 milli…
Tear-trough deformities and infraorbital hollows are common signs of aging in the periocular region and may contribute to a depressed, fatigued facial…
The two groups were well-matched for age (p = 0.105), sex (p = 0.231), years of education (p = 0.210), and body mass index (p = 0.350).;In contrast, p…
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To estimate the incidence and clinical characteristics of submacular hemorrhage (SMH) requiring procedural intervention during anti-VEGF therapy for n…
Between 2012 and 2024, 46,546 completed suicides were registered in Kazakhstan, averaging 3,580 cases per year (95% CI: 3,390-3,760).;Based on an anal…
Poorer family relationships, absence of hobbies or interests, less frequent outdoor activity, and the presence of retinopathy or another eye disease w…
Gait dysfunction is a preclinical marker of Alzheimer disease (AD) and related dementias (ADRD), often emerging years before clinical diagnosis. While…
The purpose of this in vitro study was to assess the impact of sintering protocols (conventional versus super-speed) and thermomechanical aging on the…
The overall model was statistically significant and explained a very large proportion of the variance in SBS (R2 = 0.964, adjusted R2 = 0.961).;The 3-…
Forty reports were excluded because they were reviews or commentaries, lacked a direct sustainability outcome, were not orthodontic in scope, or used …
Cancer and its treatments can have long-term adverse effects that may accelerate aging and worsen symptom burden. The cognitive and behavioral strateg…
Synapses act as core computational units that support higher cognitive functions in the brain.;Early defects in synaptic signaling and impairments in …
Transcatheter aortic valve implantation (TAVI) is increasingly performed in older adults with severe aortic stenosis, but there is limited evidence on…
Interestingly, positive endosomes are not present in every cell or every animal and can vary from just a few to hundreds.;We found that regulates loca…
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值得记进版图的原因是「二级蛋白病」这个提法:病灶里不只有主角。如果这条在哺乳动物里复现,那么「单一靶点清除」的效果上限就有了另一个解释。
Using porcine hemagglutinating encephalomyelitis virus (PHEV) as a model, we identify TRAPγ in a genome-wide CRISPR-Cas9 screen as essential for produ…