时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Low socioeconomic position (SEP) is a significant determinant of poor health. The embodiment of SEP into biology functioning and then on health status involves chronic stress mechanisms, which may be measured by allostatic load (AL). This article examines how different dimensions of SEP, representing life-course exposures shape AL trajectories, according to sex. We aim to provide evidence of this relationship over time through repeated biological measurements, which is rarely done in the literature.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★☆☆☆☆ 方法学进展决定我们能否在有限样本下检出真实效应，属基础设施级收益。队列：ELSA；最大样本量约 12,135。
原文题录
- 英文标题：Socioeconomic position and biological wear and tear in older adults: Allostatic load trajectories from the ELSA study.
- 期刊与标识：Brain Behav Immun · PMID 42957062 · DOI 10.1016/j.bbi.2026.107087
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。