时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
We highlight emerging evidence regarding fertility, menopause, and age-related comorbidities, identify critical knowledge gaps, and discuss opportunities to improve women-centered care, health equity, and healthy aging for women living with SCD worldwide.
方法
A Brazilian cohort reported menopause approximately five years earlier than expected in the general population, at approximately 46–48 years of age ().；More recent observational studies from U.S. cohorts have similarly reported mean ages of menopause in the mid-to-late 40s (, ).；In one cohort, up to 80% of women reported a reduction in vaso-occlusive pain frequency after menopause (), raising the possibility that hormonal changes may influence pain pathways or disease expression.
核心结论
Although historically associated with high childhood mortality, survival has substantially improved in many regions of the world.；The global number of individuals living with SCD increased to an estimated 7.74 million in 2021, reflecting both population growth and improved survival across the lifespan ().；Cerebrovascular injury, including silent cerebral infarction and overt stroke, contributes to cognitive impairment and reduced quality of life across the lifespan. ‖ 结论：Emerging observational data suggest that menopause may occur earlier in women with SCD, but the timing, symptom burden, and long-term health consequences of reproductive aging remain incompletely characterized.
局限
Emerging observational data suggest that menopause may occur earlier in women with SCD, but the timing, symptom burden, and long-term health consequences of reproductive aging remain incompletely characterized.；Future research should move beyond describing age at menopause to prospectively characterize the menopausal transition and its relationship to SCD disease manifestations and aging-related outcomes.
对本项目的价值
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全文来源
PMC JATS 全文（正文 24,587 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：From menarche to menopause: a lifespan perspective on women's health in sickle cell disease.
- 期刊与标识：Front Epidemiol · PMID 42964149 · DOI 10.3389/fepid.2026.1931488
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