时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Normal-tissue proteomics can contextualize senescence-associated and ferroptosis-related protein programs. We analyzed 580 normal human tissue specimens (466 adult and 114 fetal) representing 9 adult and 8 fetal Patient IDs. After excluding 748 all-missing proteins, 12,861 proteins were retained. The matrix contained 64.28% missing entries. Pathway scoring used 20 stochastic downshift completions as a model-conditional Monte Carlo ensemble, rather than formal multiple imputation. Across 41 adult tissue categories with at least three specimens, the senescence-associated proteomic proxy was highest in gall bladder and bone and lowest in spinal cord. Observed LGALS7, H1-3, MYH2, MYL1, and GFAP …
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.2/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：全身正常组织蛋白质组学框架绘制衰老相关与铁死亡相关蛋白程序的组织差异
- 英文标题：An Integrated Whole-Body Normal-Tissue Proteomics Framework Maps Tissue Variation in Senescence-Associated and Ferroptosis-Related Protein Programs.
- 期刊与标识：Proteomics · PMID 42968465 · DOI 10.1002/pmic.70202 · EDAT 2026-11-02