时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Radiotherapy combined with immunotherapy has emerged as a promising therapeutic strategy across multiple cancer types. However, despite encouraging findings from selected clinical trials, most radioimmunotherapy studies have shown only limited or even negative results, highlighting important biological barriers that limit therapeutic efficacy. Accumulating evidence suggests that radiotherapy induces phenotypic and functional changes in immune cells that resemble key features of age-related immunosenescence, including thymic involution, persistent low-grade inflammation, impaired immune reconstitution, and the accumulation of senescent cells. In this review, we systematically characterize thi…
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.7/5（★★★☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：放射免疫治疗中的免疫衰老：从生物学机制到治疗机会
- 英文标题：Immunosenescence in radio-immunotherapy: from biological mechanisms to therapeutic opportunities?
- 期刊与标识：Ageing Res Rev · PMID 42966512 · DOI 10.1016/j.arr.2026.103434 · EDAT 2026-10-31