时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
BACKGROUND: Senolytics are small-molecule drugs that selectively induce apoptosis in senescent cells, thereby reducing the chronic inflammation and tissue damage caused by the senescence-associated secretory phenotype (SASP) and delaying aging, improving organ function and extending healthspan. Existing senolytics, however, often suffer from low bioavailability and off-target toxicity, so potent and safer senolytics are urgently needed. PURPOSE: To screen for novel senolytic compounds and validate the ability of cepharanthine (CEP) to eliminate senescent cells, improve organ function and extend lifespan. STUDY DESIGN: Preclinical study combining in vitro phenotypic screening and mechanistic …
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；衰老细胞 / senolytics 机制与靶点验证栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.2/5（★★☆☆☆）
全文不可及原因
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原文题录
- 中文题名：千金藤素作为新型 senolytic：经细胞存活信号通路选择性清除衰老细胞
- 英文标题：Identification of cepharanthine as a novel senolytic that selectively eliminates senescent cells by regulating cell survival signaling pathways.
- 期刊与标识：Phytomedicine · PMID 42966158 · DOI 10.1016/j.phymed.2026.158875 · EDAT 2026-10-31