时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
BACKGROUND: Osteoarthritis (OA) is a common age-related joint disease characterized by cartilage loss and synovitis. Cellular senescence contributes to chronic inflammation through senescence-associated secretory phenotypes (SASPs). Recent evidence indicates that senescent synovial fibroblasts (SFs) contribute to OA pathogenesis. However, the in vitro modeling of the microenvironment formed by senescent SFs via SASPs remains limited. Here, we developed a three-dimensional (3D) senescent synovial organoid model using senescent rat SFs. METHODS: We created the senescent SFs by treating normal rat SFs in monolayer culture with hydrogen peroxide (H2O2). Senescence induction was confirmed by sene…
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.2/5（★★☆☆☆）
全文不可及原因
标注 OA 但 PDF 下载失败或未通过题名指纹归属校验
原文题录
- 中文题名：氧化应激处理大鼠滑膜成纤维细胞构建衰老滑膜类器官模型
- 英文标题：Generation of a senescent synovial organoid model using rat synovial fibroblasts treated with oxidative stress.
- 期刊与标识：Inflamm Regen · PMID 42968193 · DOI 10.1186/s41232-026-00436-2 · EDAT 2026-11-01