时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
Senescent cells, which accumulate with age and contribute to age-related diseases such as chronic kidney disease (CKD), have emerged as therapeutic targets. In this study, we investigated the effects of lactitol, a food-derived compound, in aged mice with adenine-induced CKD. We hypothesized that oral administration of lactitol would reduce senescence-associated cellular burden and improve renal function in aged mice with adenine-induced CKD. Oral administration of lactitol significantly reduced cecal and fecal pH, accompanied by marked decreases in renal expression of the stress-, senescence-, and fibrosis-related markers p21, Acta2, and Col1a1. Furthermore, serum levels of urea nitrogen an…
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.2/5（★★☆☆☆）
全文不可及原因
标注 OA 但 PDF 下载失败或未通过题名指纹归属校验
原文题录
- 中文题名：乳糖醇降低腺嘌呤诱导 CKD 老年小鼠的肾功能障碍与衰老标志物
- 英文标题：Lactitol Reduces Renal Dysfunction and a Senescence Marker in Aged Mice with Adenine-Induced CKD.
- 期刊与标识：J Nutr Sci Vitaminol (Tokyo) · PMID 42968248 · DOI 10.3177/jnsv.72.438 · EDAT 2026-11-01