时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Table IV indicated a significant association between CV of hs-CRP and the incidence of lung cancer (HR, 0.77; 95% CI, 0.63-0.96; P=0.018; Table IV).To explore whether the association between hs-CRP variability and cancer exists in populations with different characteristics, subgroup analyses were performed.；In the present observational study, we hypothesize that stable hs-CRP levels may represent one manifestations of immunosenescence, whereas greater hs-CRP variability might reflect a more dynamic inflammatory state.；As no direct measures of immunosenescence were available in the cohort, further exploration of whether hs-CRP variability is associated with immune aging was not possible.
方法
Cancer treatment imposes substantial physical and psychological suffering on patients and places a marked financial burden on them (5,6).；This multifaceted issue expands beyond individual patients, affecting families, careers and the broader society (7).；A previous prospective cohort study reported a notable association between elevated hs-CRP levels and cancer risk (17).
核心结论
Moreover, our previous studies have further supported this association, demonstrating a link between elevated hs-CRP levels and unfavorable survival outcomes across multiple cancer types (18,19).；Collectively, these studies indicate a strong association between hs-CRP and cancer; however, a key limitation is that hs-CRP levels were measured only once at baseline.Nonetheless, cancer development is often associated with the long-term effects of risk factors.；RCS was then used to observe the association between continuous CV of hs-CRP and cancer risk, and the results demonstrated that as CV increased, HR decreased, suggesting that higher visit-to-visit variability of hs-CRP was associated with lower cancer risk (Fig. 2A).
局限
Collectively, these studies indicate a strong association between hs-CRP and cancer; however, a key limitation is that hs-CRP levels were measured only once at baseline.Nonetheless, cancer development is often associated with the long-term effects of risk factors.；Relying solely on baseline hs-CRP levels as a predictor of cancer development has limitations.；However, since the exposure definition differed, the inclusion and exclusion criteria and the final analytical sample were not identical.
对本项目的价值
中等价值：属「免疫衰老与慢性炎症」方向；免疫 / 炎症与衰老栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 32,273 字符，题名指纹 0.92，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：高敏 C 反应蛋白变异性与癌症发病风险：纵向前瞻性队列研究
- 英文标题：High sensitivity-C-reactive protein variability and risk of cancer incidence: A longitudinal prospective cohort study cancer.
- 期刊与标识：Experimental and therapeutic medicine · PMID 42974276 · DOI 10.3892/etm.2026.13344 · PMC PMC13725645