时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Accordingly, the present study was designed to evaluate whether the combined administration of p-coumaric acid (pCA) and metformin (Met) could potentiate the cytotoxic effects of carboplatin and epirubicin in AGS gastric cancer cells.Materials and methodsReagents and Cell Culture:Human gastric cell line AGS (Pasteur Institute, Iran) was cultured in RPMI 1640 culture medium (BioIdea, Iran).
方法
Despite progress in treatments, gastric cancer patients have low survival rates because the disease typically remains silent until it has advanced beyond curability.；Even with refined surgeries, improved chemotherapy, and newer targeted or immunotherapies, most patients are diagnosed only after the cancer has spread regionally or metastasized, at which point long-term survival is rare.；While early-stage patients may achieve remission, the majority face a prognosis of months, not years.
核心结论
In many preclinical and some clinical studies, these integrated strategies have demonstrated higher anticancer effects compared to either approach alone, including better suppression of tumor growth, reduced metastasis, and prolonged survival in gastric cancer models [8, 9].A growing body of evidence has demonstrated that p-coumaric acid (pCA) and metformin (Met) possess significant antitumor activity. pCA is a phenolic compound found in fruits, vegetables, and cereals.；Although metformin is primarily prescribed for the management of type 2 diabetes, accumulating evidence indicates that it also exerts anticancer effects in multiple tumor types, such as gastric, ovarian, and endometrial cancers [14-17].Metformin has been shown to enhance the cytotoxic effects of the anticancer drug carboplatin in cases of ovarian cancer [18, 19]. lung cancer [20], breast cancer [21], and cervical cancer [22].；After obtaining the MTT test results, GraphPad Prism Software Version 10 was used to determine the IC50 values for carboplatin and epirubicin.RESULTS AND DISCUSSIONMTT assay results demonstrated that exposure of AGS gastric cancer cells to carboplatin for 48 h produced a concentration-dependent reduction in cell viability.
局限
However, recent projections indicate that the global burden is shifting: although East Asia still accounts for the largest number of cases, the most rapid increases in the coming decades are expected in sub-Saharan Africa, driven by population ageing and demographic transitions.；However, the treatments for gastric cancer are expensive and cause several side effects [6].；Furthermore, chemotherapeutic drug resistance is another limitation increasing the complexity of gastric cancer treatment.
对本项目的价值
中等价值：属「干预策略与临床转化」方向；干预策略与临床试验栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 15,611 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：对香豆酸联合二甲双胍增强卡铂与表柔比星对胃癌细胞系 AGS 的细胞毒性
- 英文标题：A combination of p-coumaric acid and metformin enhances the cytotoxicity of carboplatin and epirubicin in the gastric cancer cell line AGS.
- 期刊与标识：Molecular biology research communications · PMID 42979144 · DOI 10.22099/mbrc.2026.56296.2311 · PMC PMC13729775